{"id":112186,"date":"2026-07-09T13:19:24","date_gmt":"2026-07-09T07:49:24","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=112186"},"modified":"2026-07-09T13:19:24","modified_gmt":"2026-07-09T07:49:24","slug":"hemophagocytic-lymphohistiocytosis","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/hemophagocytic-lymphohistiocytosis\/","title":{"rendered":"Hemophagocytic Lymphohistiocytosis (HLH)"},"content":{"rendered":"<h2><b>Hemophagocytic Lymphohistiocytosis Latest News<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Former Afghanistan fast bowler Shapoor Zadran died at the age of 38 recently after battling Hemophagocytic Lymphohistiocytosis (HLH), a rare immune system disorder.<\/span><\/p>\n<h2><b>About Hemophagocytic Lymphohistiocytosis\u00a0<\/b><\/h2>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">It is a <\/span><b>rare <\/b><span style=\"font-weight: 400;\">but serious condition in which the <\/span><b>body&#8217;s immune system becomes overactive.\u00a0<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Instead of protecting the body from infections, the<\/span><b> immune system <\/b><span style=\"font-weight: 400;\">starts <\/span><b>attacking healthy tissues and organs.\u00a0<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">This causes <\/span><b>severe inflammation<\/b><span style=\"font-weight: 400;\"> that can affect the <\/span><b>liver, spleen, bone marrow, brain, <\/b><span style=\"font-weight: 400;\">and other parts of the body.\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">The condition can become<\/span><b> life-threatening if left untreated.\u00a0<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">HLH can <\/span><b>occur for different reasons<\/b><span style=\"font-weight: 400;\">. It is mainly <\/span><b>divided into two types:<\/b><\/li>\n<li style=\"text-align: justify;\"><b>Primary (Familial) HLH:\u00a0<\/b>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">This type is caused by <\/span><b>genetic changes <\/b><span style=\"font-weight: 400;\">passed down from parents.\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">It <\/span><b>usually appears during infancy or early childhood,<\/b><span style=\"font-weight: 400;\"> although it can sometimes develop later in life.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">If both parents are genetic carriers of HLH, a child has a 25% chance of having the disease, a 25% chance of not having the disease, and a 50% chance of being a carrier.\u00a0\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"text-align: justify;\"><b>Secondary (Acquired) HLH:<\/b><span style=\"font-weight: 400;\">\u00a0<\/span>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">This type develops due to <\/span><b>medical conditions that trigger the immune system.\u00a0<\/b><\/li>\n<li style=\"text-align: justify;\"><b>Common trigger<\/b><span style=\"font-weight: 400;\">s include:<\/span>\n<ul>\n<li style=\"text-align: justify;\"><b>Viral infections<\/b><span style=\"font-weight: 400;\"> such as Epstein-Barr virus (EBV) or cytomegalovirus (CMV)<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Certain <\/span><b>bacterial, fungal, or parasitic infections<\/b><\/li>\n<li style=\"text-align: justify;\"><b>Autoimmune diseases <\/b><span style=\"font-weight: 400;\">like lupus or <strong><a href=\"https:\/\/vajiramandravi.com\/current-affairs\/rheumatoid-arthritis-ra\/\" target=\"_blank\">rheumatoid arthritis<\/a><\/strong><\/span><\/li>\n<li style=\"text-align: justify;\"><b>Blood cancers<\/b><span style=\"font-weight: 400;\"> such as lymphoma or leukemia<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">A <\/span><b>weakened immune system <\/b><span style=\"font-weight: 400;\">due to certain medications or medical conditions<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>Common Symptoms Of <\/b><b>Hemophagocytic Lymphohistiocytosis<\/b><\/h2>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">The symptoms of HLH often <\/span><b>resemble those of severe infections<\/b><span style=\"font-weight: 400;\">, making it difficult to diagnose in the early stages.\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Symptoms may <\/span><b>include<\/b><span style=\"font-weight: 400;\">:\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Persistent<\/span><b> high fever<\/b>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Extreme tiredness and weakness<\/span><\/li>\n<li style=\"text-align: justify;\"><b>Enlarged liver and spleen<\/b><\/li>\n<li style=\"text-align: justify;\"><b>Swollen lymph nodes<\/b><\/li>\n<li style=\"text-align: justify;\"><b>Skin rash<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Easy bruising or bleeding<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Pale skin due to anemia<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Low blood cell counts<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Yellowing of the skin or eyes (jaundice)<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Confusion, seizures, or other neurological symptoms in severe cases<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>Hemophagocytic Lymphohistiocytosis <\/b><b>Treatment<\/b><\/h2>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">HLH treatment<\/span><b> depends on the cause, the patient&#8217;s age<\/b><span style=\"font-weight: 400;\"> when the disease starts, and how severe the disease is.\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><b>Chemotherapy and cancer drugs, immunotherapy, steroids <\/b><span style=\"font-weight: 400;\">that fight inflammation, antibiotics, and <\/span><b>antiviral drugs<\/b><span style=\"font-weight: 400;\"> are all mentioned as part of the treatment protocol. <\/span><\/li>\n<\/ul>\n<p><b>News<\/b><strong>: <a href=\"https:\/\/www.ndtv.com\/health\/what-is-the-rare-disease-that-caused-afghan-cricketer-shapoor-zadrans-death-11742860\" target=\"_blank\" rel=\"nofollow noopener\">NDTV<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hemophagocytic Lymphohistiocytosis is a rare but serious condition in which the body&#8217;s immune system becomes overactive. Read more about Hemophagocytic Lymphohistiocytosis (HLH), Symptoms, Treatment, Latest News.<\/p>\n","protected":false},"author":23,"featured_media":112224,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[8598],"class_list":["post-112186","post","type-post","status-publish","format-standard","has-post-thumbnail","category-upsc-prelims-current-affairs","tag-hemophagocytic-lymphohistiocytosis-hlh","no-featured-image-padding"],"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/112186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=112186"}],"version-history":[{"count":4,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/112186\/revisions"}],"predecessor-version":[{"id":112264,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/112186\/revisions\/112264"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/112224"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=112186"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=112186"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=112186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}