{"id":11651,"date":"2023-06-04T04:17:18","date_gmt":"2023-06-03T22:47:18","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=11651"},"modified":"2025-03-30T03:53:33","modified_gmt":"2025-03-29T22:23:33","slug":"what-are-fixed-dose-combination-fdc-drugs","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/what-are-fixed-dose-combination-fdc-drugs\/","title":{"rendered":"What are Fixed-Dose Combination (FDC) Drugs?"},"content":{"rendered":"<h2><strong>About Fixed-Dose Combination (FDC) Drugs:<\/strong><\/h2>\n<ul>\n<li>A FDC drug <strong>includes two or more active pharmaceutical ingredients (APIs) combined in a single dosage form<\/strong>, which is manufactured and <strong>distributed in fixed doses.<\/strong><\/li>\n<li>They have been shown to <strong>appreciably reduce the risk of medication non-adherence,<\/strong> which is particularly important in patients with chronic diseases.<\/li>\n<li>However, <strong>their rationality for use should be based on sound medical principles<\/strong> as there have been concerns with their irrationality and utility in several countries.<\/li>\n<li><strong>Common examples: Cough syrups Phensedyl and Corex, Vicks Action 500.<\/strong><\/li>\n<li><strong>Advantages of FDCs:<\/strong>\n<ul>\n<li><strong>Burden of keeping track of several medications, understanding their various instructions, etc. is reduced<\/strong> which improves patient compliance and therefore improves treatment outcomes.<\/li>\n<li>The FDCs are <strong>more economic<\/strong> than single ingredient drugs.<\/li>\n<li>The <strong>manufacturing cost is quite low<\/strong> as compared to the cost of producing separate products<\/li>\n<li>Then there is <strong>Simpler logistics of distribution<\/strong>.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Disadvantages of FDCs:<\/strong>\n<ul>\n<li><strong>If an adverse drug reaction occurs from using an FDC, it may be difficult to identify the active ingredient<\/strong> responsible for causing the reaction.<\/li>\n<li><strong>If the drugs combination is not appropriate, then it can lead to some patients getting too much of an ingredient and others getting too little<\/strong>. FDCs &#8220;limit clinicians&#8217; ability to customize dosing regimens.&#8221;<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<hr \/>\n<h3>Q1)\u00a0What are active pharmaceutical ingredients (APIs)?<\/h3>\n<p>Active ingredients are the substances in drugs that are responsible for the beneficial health effects experienced by consumers. The active ingredient in a pharmaceutical drug is called an active pharmaceutical ingredient (API). An example of an API is the acetaminophen contained in a pain relief tablet.<\/p>\n<p><strong>Source:<\/strong>\u00a0<a href=\"https:\/\/www.thehindu.com\/sci-tech\/health\/govt-bans-14-combination-drugs-used-to-treat-common-ailments\/article66927674.ece\" target=\"_blank\" rel=\"nofollow noopener\"><u>Government bans 14 combination drugs used to treat common ailments<\/u><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A FDC drug includes two or more active pharmaceutical ingredients (APIs) combined in a single dosage form.<\/p>\n","protected":false},"author":5,"featured_media":11652,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":{"0":"post-11651","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/11651","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=11651"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/11651\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/11652"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=11651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=11651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=11651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}