{"id":122826,"date":"2026-09-04T14:37:33","date_gmt":"2026-09-04T09:07:33","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=122826"},"modified":"2026-09-04T14:49:08","modified_gmt":"2026-09-04T09:19:08","slug":"reverse-vaccinology","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/reverse-vaccinology\/","title":{"rendered":"Reverse Vaccinology"},"content":{"rendered":"<h2><b>Reverse Vaccinology Latest News<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Recently, a team of British scientists have taken an important first step in developing a vaccine against pneumonia by using reverse vaccinology.<\/span><\/p>\n<h2><b>About Reverse Vaccinology<\/b><\/h2>\n<ul>\n<li><span style=\"font-weight: 400;\">It is an <\/span><b>emerging concept<\/b><span style=\"font-weight: 400;\"> in the field of vaccine development.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">It is defined as an innovative approach to vaccine development that <\/span><b>utilizes bioinformatics and computational analysis.<\/b><\/li>\n<li><span style=\"font-weight: 400;\">It identifies potential <\/span><b>vaccine targets within pathogen genomes,<\/b><span style=\"font-weight: 400;\"> allowing for the modeling of epitopes and the creation of tailored vaccines for improved efficacy and safety.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Reverse vaccinology is a term coined by <\/span><b>Rino Rappuoli in 2000.<\/b><\/li>\n<li><span style=\"font-weight: 400;\">He described it as a <\/span><b>method for vaccine design<\/b><span style=\"font-weight: 400;\"> that uses the information obtainable from <\/span><b>whole-genome analysis<\/b><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<li><span style=\"font-weight: 400;\">It <\/span><b>was first applied to<\/b><span style=\"font-weight: 400;\"> development of a vaccine against serogroup B <\/span><b>Neisseria meningitidis (MenB).<\/b><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<li><span style=\"font-weight: 400;\">The concept of reverse vaccinology has also successfully been applied to many other pathogens, for example, <\/span><b>Bacillus anthracis, Streptococcus pneumonia, <a href=\"https:\/\/vajiramandravi.com\/current-affairs\/tuberculosis-tb\/\" target=\"_blank\">M. tuberculosis<\/a>.<\/b><\/li>\n<li aria-level=\"1\"><b>Mechanism<\/b>\n<ul>\n<li><b>Genome Sequencing:<\/b><span style=\"font-weight: 400;\"> It <\/span><b>involves the cloning and expression<\/b><span style=\"font-weight: 400;\"> of all the proteins in an organism\u2019s genome sequence that are predicted in silico to be surface exposed or secreted.<\/span><\/li>\n<li><b>Screening:<\/b><span style=\"font-weight: 400;\"> Then <\/span><b>each protein is screened<\/b><span style=\"font-weight: 400;\">, through <\/span><b>high-throughput immunization<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li><b>Laboratory Testing:<\/b><span style=\"font-weight: 400;\"> Scientists make <\/span><b>the chosen proteins<\/b><span style=\"font-weight: 400;\"> in a lab and test them in animal models to see if <\/span><b>they safely cause immunity.<\/b><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><b>Source: <\/b><strong><a href=\"https:\/\/www.thehindu.com\/sci-tech\/science\/a-first-step-towards-a-universal-vaccine-against-pneumonia-meningitis\/article71418988.ece\" target=\"_blank\" rel=\"nofollow noopener\">TH<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Reverse Vaccinology is defined as an innovative approach to vaccine development that utilizes bioinformatics and computational analysis. Read more about Reverse Vaccinology, Mechanism, Latest News.<\/p>\n","protected":false},"author":24,"featured_media":122772,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[21,10011,22,23],"class_list":["post-122826","post","type-post","status-publish","format-standard","has-post-thumbnail","category-upsc-prelims-current-affairs","tag-prelims-pointers","tag-reverse-vaccinology","tag-upsc-current-affairs","tag-upsc-prelims-current-affairs","no-featured-image-padding"],"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/122826","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=122826"}],"version-history":[{"count":4,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/122826\/revisions"}],"predecessor-version":[{"id":122846,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/122826\/revisions\/122846"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/122772"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=122826"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=122826"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=122826"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}