{"id":132648,"date":"2026-11-11T13:55:24","date_gmt":"2026-11-11T08:25:24","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=132648"},"modified":"2026-11-11T13:55:24","modified_gmt":"2026-11-11T08:25:24","slug":"extracellular-vesicles-evs","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/extracellular-vesicles-evs\/","title":{"rendered":"Extracellular Vesicles (EVs)"},"content":{"rendered":"<h2><b>Extracellular Vesicles Latest News<\/b><\/h2>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Extracellular vesicles (EVs) can modify pathological progression in Alzheimer\u2019s disease (AD), the most common neurodegenerative disease in older adults, by spreading pathogenic factors.<\/span><\/p>\n<h2><b>About Extracellular Vesicles<\/b><\/h2>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">EVs are <\/span><b>small membranous nanoparticles secreted by all types of cells<\/b><span style=\"font-weight: 400;\"> into the extracellular space.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">They can be <\/span><b>found in numerous bodily fluids<\/b><span style=\"font-weight: 400;\">, including <\/span><b>blood, urine, cerebrospinal fluid,<\/b><span style=\"font-weight: 400;\"> and more.\u00a0\u00a0\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">The biochemical <\/span><b>composition <\/b><span style=\"font-weight: 400;\">of EVs mainly consists of<\/span><b> lipids, proteins, and nucleic acids.\u00a0<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Derived from cells, EVs obtain their <\/span><b>appearance based on the cargo transferred from the donor cells,<\/b><span style=\"font-weight: 400;\"> known as their <\/span><b>molecular signature.<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Unlike other cellular components, EVs are <\/span><b>not capable of replication.\u00a0<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">EVs are broadly <\/span><b>classified into:<\/b>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><b>Exosomes (30\u2013150 nm):<\/b> <b>Originate <\/b><span style=\"font-weight: 400;\">from <\/span><b>endosomal compartments<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><b>Microvesicles (100\u20131000 nm)<\/b><span style=\"font-weight: 400;\">: Shed directly from the <\/span><b>plasma membrane.<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><b>Apoptotic bodies (&gt;1000 nm)<\/b><span style=\"font-weight: 400;\">: <\/span><b>Released by dying cells.<\/b><\/li>\n<\/ul>\n<\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">EVs have a<\/span><b> wide range of uses <\/b><span style=\"font-weight: 400;\">in various fields, and their therapeutic potential is currently being explored in many preclinical and clinical studies.\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><b>Intercellular communication:\u00a0<\/b>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">EVs play an important role in intercellular communication by<\/span><b> transferring biological molecules<\/b><span style=\"font-weight: 400;\">, such as proteins, lipids, and nucleic acids,<\/span><b> between cells.\u00a0<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">This process can <\/span><b>influence <\/b><span style=\"font-weight: 400;\">various<\/span><b> physiological and pathological processes,<\/b><span style=\"font-weight: 400;\"> including i<\/span><b>mmune response, tissue regeneration,<\/b><span style=\"font-weight: 400;\"> and <\/span><b>cancer progression.<\/b><\/li>\n<\/ul>\n<\/li>\n<li style=\"text-align: justify;\"><b>Diagnostic markers:\u00a0<\/b>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">EVs can serve as diagnostic markers for various diseases, as they <\/span><b>contain biomolecules<\/b><span style=\"font-weight: 400;\"> that <\/span><b>reflect <\/b><span style=\"font-weight: 400;\">the <\/span><b>physiological state of the parent cell.\u00a0<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">For example, circulating EVs have been shown to <\/span><b>contain biomarkers for cancer and neurodegenerative diseases<\/b><span style=\"font-weight: 400;\">, and their analysis can aid in disease diagnosis and prognosis.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"text-align: justify;\"><b>Drug delivery:\u00a0<\/b>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">EVs can be <\/span><b>engineered to deliver therapeutic molecules<\/b><span style=\"font-weight: 400;\">, such as drugs or nucleic acids, to target cells.\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">These offer several advantages over traditional drug delivery systems, including <\/span><b>high biocompatibility, low immunogenicity,<\/b><span style=\"font-weight: 400;\"> and the <\/span><b>ability to cross biological barriers.<\/b><\/li>\n<\/ul>\n<\/li>\n<li style=\"text-align: justify;\"><b>Tissue engineering:\u00a0<\/b>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">EVs can <\/span><b>promote tissue regeneration and repair<\/b><span style=\"font-weight: 400;\"> by modulating cellular behavior and signaling pathways.\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">These have been used in various tissue engineering applications, including <\/span><b>bone regeneration, cartilage repair,<\/b><span style=\"font-weight: 400;\"> and <\/span><b>wound healing.<\/b><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><b>News: <\/b><a href=\"https:\/\/www.nature.com\/articles\/s43587-026-01263-3\" target=\"_blank\" rel=\"nofollow noopener\"><b>NAT<\/b><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Extracellular Vesicles are small membranous nanoparticles secreted by all types of cells into the extracellular space. Read more about Extracellular Vesicles (EVs), Meaning, Classification, Importance.<\/p>\n","protected":false},"author":23,"featured_media":132614,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[11429],"class_list":["post-132648","post","type-post","status-publish","format-standard","has-post-thumbnail","category-upsc-prelims-current-affairs","tag-extracellular-vesicles","no-featured-image-padding"],"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/132648","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=132648"}],"version-history":[{"count":4,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/132648\/revisions"}],"predecessor-version":[{"id":132673,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/132648\/revisions\/132673"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/132614"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=132648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=132648"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=132648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}