{"id":23247,"date":"2025-11-15T11:09:09","date_gmt":"2025-11-15T05:39:09","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=23247"},"modified":"2025-11-18T13:47:58","modified_gmt":"2025-11-18T08:17:58","slug":"sickle-cell-disease-scd","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/sickle-cell-disease-scd\/","title":{"rendered":"Sickle Cell Disease"},"content":{"rendered":"<h2><b>Sickle Cell Disease Latest News<\/b><\/h2>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">A decade-long study by a Gurugram hospital has found success in curing Sickle Cell Disease among children through bone marrow (stem cell) transplantation, placing India among the leading nations in advanced paediatric transplant outcomes.<\/span><\/p>\n<h2><b>About Sickle Cell Disease<\/b><\/h2>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">It is a group of <\/span><b>inherited blood cell disorders<\/b><span style=\"font-weight: 400;\"> that <\/span><b>affect hemoglobin<\/b><span style=\"font-weight: 400;\">, the <\/span><b>protein that carries oxygen through the body.<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">SCD can cause <\/span><b>episodes of severe pain <\/b><span style=\"font-weight: 400;\">and lead to<\/span><b> life-threatening complications.\u00a0<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">The <\/span><b>most common and severe type <\/b><span style=\"font-weight: 400;\">of SCD is<\/span><b> sickle cell anemia.<\/b><\/li>\n<li style=\"text-align: justify;\"><b>How Does it Affect Blood Flow?<\/b>\n<ul>\n<li style=\"text-align: justify;\"><b>Normally<\/b><span style=\"font-weight: 400;\">,<\/span><b> RBCs are disc-shaped and flexible <\/b><span style=\"font-weight: 400;\">enough to move easily through the blood vessels.<\/span><\/li>\n<li style=\"text-align: justify;\"><b>People with SCD<\/b><span style=\"font-weight: 400;\"> have <\/span><b>atypical hemoglobin molecules called hemoglobin S, <\/b><span style=\"font-weight: 400;\">which can <\/span><b>distort RBCs into a sickle, or crescent, shap<\/b><span style=\"font-weight: 400;\">e.<\/span><\/li>\n<li style=\"text-align: justify;\"><b>When RBCs sickle,<\/b><span style=\"font-weight: 400;\"> they <\/span><b>do not bend or move easily <\/b><span style=\"font-weight: 400;\">and can <\/span><b>block blood flow<\/b><span style=\"font-weight: 400;\"> to the rest of the body.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">SCD i<\/span><b>nterferes with the delivery of oxygen <\/b><span style=\"font-weight: 400;\">to the tissues.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"text-align: justify;\"><b>What causes it?<\/b>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">The cause of SCD is a <\/span><b>defective gene<\/b><span style=\"font-weight: 400;\">, called a <\/span><b>sickle cell gene.<\/b><\/li>\n<li style=\"text-align: justify;\"><b>A person will be born with SCD only if two genes are inherited<\/b><span style=\"font-weight: 400;\">\u2014<\/span><b>one from the mother and one from the father.<\/b><\/li>\n<\/ul>\n<\/li>\n<li style=\"text-align: justify;\"><b>Symptoms<\/b><span style=\"font-weight: 400;\">:<\/span>\n<ul>\n<li style=\"text-align: justify;\"><b>Early stage:<\/b><span style=\"font-weight: 400;\"> E<\/span><b>xtreme tiredness or fussiness from anemia<\/b><span style=\"font-weight: 400;\">, painfully <\/span><b>swollen hands <\/b><span style=\"font-weight: 400;\">and feet, and <\/span><b>jaundice<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"text-align: justify;\"><b>Later stage<\/b><span style=\"font-weight: 400;\">: S<\/span><b>evere pain, anemia, <\/b><span style=\"font-weight: 400;\">organ damage, and infections.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"text-align: justify;\"><b>Treatments<\/b><span style=\"font-weight: 400;\">:<\/span>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">A <\/span><b>bone marrow transplant <\/b><span style=\"font-weight: 400;\">(stem cell transplant) can cure SCD.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">However, there are treatments that can help relieve symptoms, lessen complications, and prolong life.<\/span><\/li>\n<li style=\"text-align: justify;\"><b>Gene therapy<\/b><span style=\"font-weight: 400;\"> is also being explored as another potential cure.<\/span><\/li>\n<li style=\"text-align: justify;\">The<b style=\"font-size: inherit;\"> UK <\/b><span style=\"font-weight: 400;\">recently became the <\/span><b style=\"font-size: inherit;\">first country to approve gene therapy treatment<\/b><span style=\"font-weight: 400;\"> for SCD.<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong>Source: <a href=\"https:\/\/www.ndtv.com\/health\/indian-breakthrough-in-bone-marrow-transplant-to-aid-children-with-sickle-cell-disease-9630718\" target=\"_blank\" rel=\"nofollow noopener\">NDTV<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sickle Cell Disease is a group of inherited blood cell disorders that affect hemoglobin, the protein that carries oxygen through the body. Read more about Sickle Cell Disease, Causes, Symptoms, Treatments, Latest News.<\/p>\n","protected":false},"author":5,"featured_media":73578,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[21,3716,22,23],"class_list":{"0":"post-23247","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"tag-prelims-pointers","9":"tag-sickle-cell-disease","10":"tag-upsc-current-affairs","11":"tag-upsc-prelims-current-affairs","12":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/23247","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=23247"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/23247\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/73578"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=23247"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=23247"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=23247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}