{"id":25076,"date":"2024-07-16T01:55:14","date_gmt":"2024-07-15T20:25:14","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=25076"},"modified":"2025-10-08T12:53:40","modified_gmt":"2025-10-08T07:23:40","slug":"tirzepatide-and-semaglutide","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/tirzepatide-and-semaglutide\/","title":{"rendered":"Tirzepatide and Semaglutide"},"content":{"rendered":"<h2>About Tirzepatide and Semaglutide:<\/h2>\n<ul>\n<li>These two weight<strong> loss drugs<\/strong> have been approved by the FDA for chronic weight management in adults.<\/li>\n<li>Semaglutide and tirzepatide are polypeptides, <strong>small proteins<\/strong> that boost the levels of naturally-occurring hormones in the body, including that of <strong>glucagon-like-peptide 1<\/strong> (GLP-1), which control weight through the brain and digestive tract.<\/li>\n<li><strong>Functioning<\/strong>\n<ul>\n<li>Higher GLP-1 levels, released in the gut, spark a reaction by stimulating neurons that alter gut function, <strong>leading to a sense of fullness.<\/strong><\/li>\n<li>This process also <strong>taps into a brain mechanism<\/strong> that lights up neural pathways, triggering the sensation of satiety \u2014 the feeling of being satisfied and having had enough to eat.<\/li>\n<li>They also <strong>help manage glucose levels<\/strong>, making them an effective treatment for diabetes.<\/li>\n<li>Semaglutide only targets <strong>GLP-1 receptors.<\/strong><\/li>\n<li>On the other hand, tirzepatide also boosts a second hormone: glucose-<strong>dependent insulinotropic polypeptide<\/strong> (GIP).<\/li>\n<li>The GIP also regulates weight through receptors in brain and fat cells.<\/li>\n<\/ul>\n<\/li>\n<li>These drugs can be prescribed to those <strong>who are obese<\/strong> (with a body mass index of over 30), or overweight (with a BMI between 27 and 30), and have at least one other health condition related to their weight (such as high blood pressure, high cholesterol, or type 2 diabetes).<\/li>\n<li><strong>Side effects<\/strong>: Nausea, diarrhoea, vomiting, constipation, abdominal pain, indigestion, injection-site reactions, fatigue, allergic reactions, belching, hair loss, and heartburn.<\/li>\n<\/ul>\n<hr \/>\n<h3>Q1: What is Glucose?<\/h3>\n<p>It is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms.<\/p>\n<p><strong>Source: <\/strong><a href=\"https:\/\/indianexpress.com\/article\/explained\/explained-health\/weight-loss-drug-tirzepatide-how-it-works-side-effects-9453479\/\" target=\"_blank\" rel=\"nofollow noopener\">India could soon allow \u2018game-changing\u2019 weight-loss drug tirzepatide: How it works, its side effects<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tirzepatide and Semaglutide weight loss drugs have been approved by the FDA for chronic weight management in adults.<\/p>\n","protected":false},"author":5,"featured_media":25077,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":{"0":"post-25076","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/25076","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=25076"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/25076\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/25077"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=25076"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=25076"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=25076"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}