{"id":27132,"date":"2024-10-08T10:28:40","date_gmt":"2024-10-08T04:58:40","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=27132"},"modified":"2025-04-08T07:21:11","modified_gmt":"2025-04-08T01:51:11","slug":"advanced-glycation-end-products-ages","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/advanced-glycation-end-products-ages\/","title":{"rendered":"What are Advanced glycation end products (AGEs)?"},"content":{"rendered":"<h2><strong>About Advanced glycation end products (AGEs):<\/strong><\/h2>\n<ul>\n<li>AGEs (also known as <strong>glycotoxins<\/strong>) are <strong>harmful molecules<\/strong> formed by the <strong>glycation and oxidation of lipids and proteins.<\/strong>\n<ul>\n<li><strong>Glycation<\/strong> is the process of <strong>combining other molecules with sugars.<\/strong><\/li>\n<li>Oxidation is the process of combining other molecules with oxygen.\u00a0<\/li>\n<\/ul>\n<\/li>\n<li>AGEs are <strong>formed in your body by metabolism<\/strong>, but the <strong>major source<\/strong> of AGEs <strong>is food.<\/strong><\/li>\n<li>They are <strong>formed in food by<\/strong> grilling, toasting, roasting, broiling, frying, and other<strong> high-temperature cooking.\u00a0<\/strong><\/li>\n<li><strong>Tobacco use<\/strong> is yet another source of AGEs.\u00a0<\/li>\n<li><strong>AGE productionin the body increases with age.<\/strong><\/li>\n<li><strong>Why are AGEs harmful?<\/strong>\n<ul>\n<li>AGEs are <strong>present in the body at all times<\/strong>. At low levels, they don&#8217;t cause significant injury.\u00a0<\/li>\n<li>However, they <strong>cause cell and tissue damage<\/strong> when they reach <strong>high concentrations.\u00a0<\/strong><\/li>\n<li>AGEs <strong>combine with receptors<\/strong> located <strong>on blood vessels and<\/strong> several other organs to <strong>cause damage to organ systems<\/strong>.<\/li>\n<li>These compounds can <strong>impact the function of proteins<\/strong> within the cells, <strong>alter the behavior of hormones<\/strong>, cytokines, and free radicals, and modify the extracellular matrix between cells.<\/li>\n<li>AGEs <strong>activate inflammatory and other destructive processes<\/strong> in many systems of your body.\u00a0<\/li>\n<li>AGEs are involved in the development of various <strong>chronic inflammatory diseases<\/strong> such as <strong>type II diabetes mellitus,<\/strong> vascular and <strong>cardiovascular diseases,<\/strong> osteoporosis, and <strong>arthritis<\/strong>.<\/li>\n<li><strong>Hyperglycemia<\/strong> (<strong>high blood levels of glucose)<\/strong> is one condition associated with more AGE production, causing blood vessel damage in people with diabetes.\u00a0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<hr \/>\n<h3><strong>Q1<\/strong>: What are lipids?<\/h3>\n<p>Lipids are fatty compounds that perform a variety of functions in your body. They\u2019re part of your cell membranes and help control what goes in and out of your cells. They help with moving and storing energy, absorbing vitamins and making hormones. Having too much of some lipids is harmful.\u00a0<\/p>\n<p><strong>Source:<\/strong> <a href=\"https:\/\/www.thehindu.com\/news\/national\/consumption-of-ultra-processed-and-fast-foods-leading-cause-of-diabetes-in-india-reveals-new-study\/article68729384.ece\" target=\"_blank\" rel=\"nofollow noopener\">Consumption of ultra-processed and fast foods leading cause of diabetes in India, reveals new study<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Advanced glycation end products (AGEs) are harmful molecules formed by the glycation and oxidation of lipids and proteins.<\/p>\n","protected":false},"author":5,"featured_media":27133,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":{"0":"post-27132","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/27132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=27132"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/27132\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/27133"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=27132"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=27132"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=27132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}