{"id":29726,"date":"2025-01-30T12:26:15","date_gmt":"2025-01-30T06:56:15","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=29726"},"modified":"2025-04-09T10:22:49","modified_gmt":"2025-04-09T04:52:49","slug":"rna-therapy","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/rna-therapy\/","title":{"rendered":"RNA Therapy"},"content":{"rendered":"<h2>RNA Therapy Latest News<\/h2>\n<p>In recent days RNA-based precision therapeutics are emerging as a game-changer for genetic disorders, including inherited retinal diseases (IRDs).<\/p>\n<h2>About RNA Therapy<\/h2>\n<ul>\n<li>It is a term used to describe the use of <strong>RNA-based molecules<\/strong> to modulate biological pathways to cure a specific condition.\u00a0<\/li>\n<li>Unlike DNA or genome-editing therapies, RNA-based therapies <strong>offer a safer alternative<\/strong> as they make temporary changes that <strong>don\u2019t carry over to future generations<\/strong>, reducing the risk of unintended long-term effects.<\/li>\n<\/ul>\n<h2>Applications of RNA based Therapies<\/h2>\n<ul>\n<li><strong>RNA-editing with ADAR enzymes:<\/strong> It can correct specific genetic mutations at the RNA level. This method has the potential to <strong>restore protein production in retinal cells<\/strong> without altering the underlying DNA, offering a new way to treat retinal degenerative diseases caused by single-point mutations.<\/li>\n<li><strong>Using of suppressor tRNAs:<\/strong> It is to bypass <strong>stop-codon mutations<\/strong>, which can prematurely halt protein synthesis in retinal cells. By enabling the production of full-length proteins, this approach could help restore proper retinal function in IRD patients.<\/li>\n<li><strong>PTC124 Method:<\/strong> It is also <strong>known as ataluren,<\/strong> which is already being used to treat patients with <strong>cystic fibrosis and Duchenne muscular dystrophy.<\/strong><\/li>\n<li><strong>Antisense oligonucleotides (ASOs)<\/strong> have already been used successfully to treat diseases such as <strong>spinal muscular atrophy and Duchenne muscular dystrophy.<\/strong><\/li>\n<\/ul>\n<h2>RNA Therapy FAQs<\/h2>\n<p><strong>Q1:<\/strong> What is RNA used for?<\/p>\n<p><strong>Ans:<\/strong> It is used for carrying biological information, providing structure, facilitating chemical reactions and regulating the functions of DNA and other RNA molecules.<\/p>\n<p><strong>Q2:<\/strong> What does RNA stand for in therapy?<\/p>\n<p><strong>Ans:<\/strong> RNA stands for ribonucleic acid and it is a similar molecule to DNA.<\/p>\n<p><strong>Q3:<\/strong> What is an example of RNA therapy?<\/p>\n<p><strong>Ans:<\/strong> antisense oligonucleotide (ASO), small interfering RNA (siRNA), and microRNA (miRNA) therapies.<\/p>\n<p><strong>Q4:<\/strong> What are the benefits of RNA?<\/p>\n<p><strong>Ans:<\/strong> beneficial for injury recovery, post-surgery healing, memory support, digestive health, and managing the visible signs of aging.<\/p>\n<p><strong>Source: <\/strong><a href=\"https:\/\/www.thehindu.com\/sci-tech\/science\/inherited-retinal-diseases-rna-therapeutics-promise-india\/article69143245.ece\" target=\"_blank\" rel=\"nofollow noopener\">TH\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>RNA Therapy is a term used to describe the use of RNA-based molecules to modulate biological pathways to cure a specific condition.<\/p>\n","protected":false},"author":5,"featured_media":29727,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":{"0":"post-29726","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/29726","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=29726"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/29726\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/29727"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=29726"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=29726"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=29726"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}