{"id":3114,"date":"2024-06-29T09:38:23","date_gmt":"2024-06-29T04:08:23","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=3114"},"modified":"2025-03-26T10:23:44","modified_gmt":"2025-03-26T04:53:44","slug":"vascular-endothelial-growth-factor","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/vascular-endothelial-growth-factor\/","title":{"rendered":"Vascular Endothelial Growth Factor Receptor"},"content":{"rendered":"<h2>About Vascular Endothelial Growth Factor Receptor (VEGF):\u00a0<\/h2>\n<ul>\n<li>It is a key regulator of <strong>physiological angiogenesis<\/strong> during embryogenesis, skeletal growth and reproductive functions.<\/li>\n<li>VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions.<\/li>\n<li>The biological effects of VEGF are mediated by two receptor tyrosine kinases (RTKs), VEGFR-1 and VEGFR-2.<\/li>\n<li>The VEGFR family of receptors is the <strong>key regulator<\/strong> of the process of <strong>generating new blood vessels.<\/strong><\/li>\n<\/ul>\n<p><strong>Highlight of the research<\/strong><\/p>\n<ul>\n<li>The researchers were intrigued by the fact that two members of family VEGFR 1 and VEGFR 2 <strong>behaved quite differently.<\/strong><\/li>\n<li>While VEGFR 2, the primary receptor regulating process of formation of new blood vessels, could be <strong>spontaneously activated<\/strong>, without its ligand, the other member of the family VEGFR 1 cannot be spontaneously activated even when overexpressed in cells.<\/li>\n<li>It <strong>camouflages as a dead enzyme VEGFR1 <\/strong>and binds with ten-fold higher affinity to its ligand VEGF-A than VEGFR2.<\/li>\n<li>This ligand binding induces a transient kinase (speeding up chemical reactions in the body by an enzyme) activation.<\/li>\n<\/ul>\n<hr \/>\n<h3>Q1: What are Endothelial cells?<\/h3>\n<p>These form a single cell layer that lines all blood vessels and regulates exchanges between the bloodstream and the surrounding tissues.<\/p>\n<p><strong>Source: <\/strong><a href=\"https:\/\/pib.gov.in\/PressReleasePage.aspx?PRID=2029236\" target=\"_blank\" rel=\"nofollow noopener\">Camouflaging as a dead enzyme VEGFR1 holds key to medical solutions for colon and renal cancers<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vascular Endothelial Growth Factor Receptor  is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions.<\/p>\n","protected":false},"author":5,"featured_media":3115,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":{"0":"post-3114","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/3114","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=3114"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/3114\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/3115"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=3114"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=3114"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=3114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}