{"id":32004,"date":"2025-04-14T06:26:23","date_gmt":"2025-04-14T00:56:23","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=32004"},"modified":"2025-04-16T18:28:03","modified_gmt":"2025-04-16T12:58:03","slug":"signet-ring-cell-carcinoma-srcc","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/signet-ring-cell-carcinoma-srcc\/","title":{"rendered":"Signet Ring Cell Carcinoma (SRCC)"},"content":{"rendered":"<h2>Signet Ring Cell Carcinoma (SRCC) Latest News<\/h2>\n<p>Recently, a team of Indian scientists has developed novel analytical methods to study and potentially treat Rare Colorectal Cancer (SRCC) more effectively.<\/p>\n<h2>What is Signet Ring Cell Carcinoma (SRCC)?<\/h2>\n<ul>\n<li><strong>Signet Ring Cell Carcinoma (SRCC)<\/strong> is a <strong>rare and aggressive subtype<\/strong> of <strong>colorectal cancer (CRC)<\/strong> that originates in the <strong>colon or rectum<\/strong>.<\/li>\n<li>It is named for the <strong>signet ring-like appearance<\/strong> of its cells under a microscope, caused by <strong>mucus pushing the nucleus to one side<\/strong>.<\/li>\n<li>SRCC is known for its <strong>rapid spread<\/strong>, <strong>resistance to conventional therapies<\/strong>, and <strong>late-stage diagnosis<\/strong>, making it one of the <strong>deadliest colon cancer variants<\/strong>.<\/li>\n<\/ul>\n<h2>What Are the Innovative Methods Introduced?<\/h2>\n<ul>\n<li>The researchers developed <strong>Patient-Derived Organoids (PDOs)<\/strong> and <strong>Patient-Derived Xenografts (PDXs):<\/strong>\n<ul>\n<li><strong>PDOs<\/strong> are miniature 3D tumour models grown from <strong>human cancer tissues<\/strong> in lab dishes.<\/li>\n<li><strong>PDXs<\/strong> involve <strong>implanting human tumour cells into mice<\/strong>, enabling the tumour to grow in a <strong>living system<\/strong>.<\/li>\n<\/ul>\n<\/li>\n<li>These <strong>lab-grown models<\/strong> closely mimic the <strong>molecular behaviour<\/strong> of actual human SRCC tumours.<\/li>\n<li>This method forms <strong>one of the first living biobanks<\/strong> of SRCC models, enabling researchers to <strong>study the disease more precisely<\/strong> and test treatments in a <strong>controlled environment<\/strong>.<\/li>\n<li>A major difficulty in treating SRCC is its tendency to <strong>spread to the peritoneum<\/strong>, the <strong>lining of the abdominal cavity<\/strong>, which worsens the <strong>prognosis<\/strong> and reduces treatment effectiveness.<\/li>\n<li>While SRCC makes up only <strong>1% of all CRC cases globally<\/strong>, in <strong>India<\/strong>, it affects a <strong>disproportionately larger number<\/strong> of patients \u2014 nearly <strong>10 times more<\/strong>, often in <strong>younger individuals<\/strong>.<\/li>\n<\/ul>\n<h2>Signet Ring Cell Carcinoma (SRCC) FAQs<\/h2>\n<p><strong>Q1. <\/strong>What is Signet Ring Cell Carcinoma (SRCC)?<br \/>\n<strong>Ans.<\/strong> SRCC is an aggressive cancer subtype marked by cells resembling signet rings (cytoplasm pushed to periphery by mucin). It commonly affects the stomach, colon, or breast.<\/p>\n<p><strong>Q2. <\/strong>Why is SRCC clinically significant?<br \/>\n<strong>Ans. <\/strong>It has a poor prognosis due to late diagnosis, rapid metastasis, and resistance to chemotherapy. Early detection via endoscopy\/biopsy is critical.<\/p>\n<p><strong>Q3.<\/strong> What are the risk factors for SRCC?<br \/>\n<strong>Ans.<\/strong> Genetic predisposition (CDH1 mutations), chronic inflammation (e.g., <i>H. pylori<\/i> infection), and lifestyle factors like smoking.<\/p>\n<p><strong>Source: <\/strong><a href=\"https:\/\/indianexpress.com\/article\/explained\/explained-health\/explained-how-scientists-developed-a-new-way-of-examining-rare-cancer-9942586\/\" target=\"_blank\" rel=\"nofollow noopener\">IE<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Signet Ring Cell Carcinoma (SRCC) is a rare and aggressive subtype of colorectal cancer (CRC) that originates in the colon or rectum.<\/p>\n","protected":false},"author":5,"featured_media":32005,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":{"0":"post-32004","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/32004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=32004"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/32004\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/32005"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=32004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=32004"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=32004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}