{"id":3658,"date":"2023-03-03T09:30:53","date_gmt":"2023-03-03T04:00:53","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=3658"},"modified":"2025-03-26T17:02:05","modified_gmt":"2025-03-26T11:32:05","slug":"indias-dna-vaccine-against-dengue","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/indias-dna-vaccine-against-dengue\/","title":{"rendered":"India\u2019s DNA Vaccine against Dengue"},"content":{"rendered":"<h2><strong>Why in News?<\/strong><\/h2>\n<ul>\n<li>The DNA vaccine has been in development since 2019 by scientists from the National Centre for Biological Sciences (NCBS), Bengaluru, in collaboration with nine institutions in India, Africa, and the US.<\/li>\n<\/ul>\n<h3><strong>About DNA Vaccine:<\/strong><\/h3>\n<ul>\n<li>DNA vaccines use <strong>engineered DNA to induce an immunologic response in the host against bacteria, parasites, and viruses.<\/strong><\/li>\n<li>The <strong>basic working principle<\/strong> behind DNA vaccine <strong>involves the use of a DNA plasmid that encodes for a protein<\/strong> <strong>that originated from the pathogen<\/strong> in which the vaccine will be targeted.<\/li>\n<li>DNA vaccine will <strong>avoid extracellular degradation<\/strong> and <strong>successfully enter the nucleus of target cells<\/strong> to induce a long-term immune response.<\/li>\n<li>It is considered to be <strong>more stable, cost-efficient, and easier to handle<\/strong> than traditional vaccines.<\/li>\n<\/ul>\n<h3><strong>Dengue disease:<\/strong><\/h3>\n<ul>\n<li>Dengue is a mosquito-borne viral infection <strong>found in tropical and sub-tropical climates <\/strong>worldwide, mostly in urban and semi-urban areas.<\/li>\n<li>The primary vectors that transmit the disease are <strong>Aedes aegypti mosquitoes<\/strong>.<\/li>\n<li>The <strong>virus<\/strong> responsible for causing dengue is called the <strong>dengue virus (DENV).<\/strong><\/li>\n<li>It can be <strong>transmitted to humans through the bite of infected mosquitoes.<\/strong><\/li>\n<li>The World Health Organization (WHO) also states that the <strong>virus can transmit from pregnant mother to baby.<\/strong><\/li>\n<li>There is <strong>no specific treatment for dengue\/severe dengue<\/strong>. Early detection of disease progression associated with severe dengue and access to proper medical care lowers fatality rates of severe dengue to below 1%.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<hr \/>\n<h3>Q1) What is a Plasmid?<\/h3>\n<p>A plasmid is a small, circular, double-stranded DNA molecule that is distinct from a cell&#8217;s chromosomal DNA. Plasmids naturally exist in bacterial cells, and they also occur in some eukaryotes<\/p>\n<p><strong>Source:<\/strong>\u00a0<a href=\"https:\/\/www.downtoearth.org.in\/news\/health\/decoding-dengue-india-s-first-prospective-dna-vaccine-against-disease-is-promising-but-challenges-lie-ahead-87951\" target=\"_blank\" rel=\"nofollow noopener\"><u>Down to Earth<\/u><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DNA vaccines use engineered DNA to induce an immunologic response in host against bacteria, parasites, viruses.<\/p>\n","protected":false},"author":5,"featured_media":3659,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":{"0":"post-3658","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/3658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=3658"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/3658\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/3659"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=3658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=3658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=3658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}