{"id":42213,"date":"2025-04-20T11:05:30","date_gmt":"2025-04-20T05:35:30","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=42213"},"modified":"2025-05-28T12:46:02","modified_gmt":"2025-05-28T07:16:02","slug":"stem-cell-therapy-for-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/stem-cell-therapy-for-parkinsons-disease\/","title":{"rendered":"Stem Cell Therapy for Parkinson\u2019s Disease"},"content":{"rendered":"<h2>Stem Cell Therapy for Parkinson\u2019s Disease Latest News<\/h2>\n<p>Researchers at Kyoto University conducted a Phase I\/II clinical trial to assess the safety and side effects of stem cell therapy using dopaminergic progenitors derived from human induced pluripotent stem cells (iPSCs).<\/p>\n<h2>About Parkinson\u2019s Disease<\/h2>\n<ul>\n<li><strong>Parkinson\u2019s disease<\/strong>\u00a0is a\u00a0<strong>neurodegenerative disorder<\/strong>\u00a0that causes the\u00a0<strong>progressive loss of dopamine-producing neurons<\/strong>\u00a0in the brain.<\/li>\n<li><strong>Dopamine<\/strong>\u00a0is a critical\u00a0<strong>neurotransmitter<\/strong>\u00a0responsible for regulating\u00a0<strong>motor functions<\/strong>.<\/li>\n<li>The conventional treatment mainly involves\u00a0<strong>dopaminergic medications<\/strong>, but these\u00a0<strong>do not restore lost neurons<\/strong>\u00a0and may have\u00a0<strong>long-term side effects<\/strong>.<\/li>\n<\/ul>\n<h2>Induced Pluripotent Stem Cells (iPSCs)<\/h2>\n<ul>\n<li><strong>iPSCs<\/strong>\u00a0are\u00a0<strong>pluripotent stem cells<\/strong>\u00a0generated from\u00a0<strong>adult somatic cells<\/strong>\u00a0(like skin or blood).<\/li>\n<li>They are\u00a0<strong>reprogrammed<\/strong>\u00a0to an embryonic-like state, allowing them to develop into\u00a0<strong>any human cell type<\/strong>.<\/li>\n<li>Used in:\n<ul>\n<li><strong>Diabetes<\/strong>\u00a0(converted into\u00a0<strong>beta cells<\/strong>),<\/li>\n<li><strong>Leukaemia<\/strong>\u00a0(to generate new blood cells),<\/li>\n<li><strong>Neurological diseases<\/strong>.<\/li>\n<\/ul>\n<\/li>\n<li>iPSCs are valuable in\u00a0<strong>drug testing<\/strong>,\u00a0<strong>disease modelling<\/strong>, and\u00a0<strong>transplantation medicine<\/strong>.<\/li>\n<\/ul>\n<h2>Stem Cells<\/h2>\n<ul>\n<li><strong>Stem cells<\/strong>\u00a0are\u00a0<strong>undifferentiated primitive cells<\/strong>\u00a0capable of developing into\u00a0<strong>specialised cells<\/strong>\u00a0like blood, muscle, or liver cells.<\/li>\n<li>Their ability to\u00a0<strong>self-renew and differentiate<\/strong>\u00a0makes them vital for\u00a0<strong>regeneration and repair<\/strong>.<\/li>\n<li>Found in:\n<ul>\n<li><strong>Bone marrow<\/strong>,<\/li>\n<li><strong>Gastrointestinal tract<\/strong>\u00a0(divide regularly),<\/li>\n<li>Less active in organs like the\u00a0<strong>pancreas<\/strong>\u00a0or the\u00a0<strong>heart<\/strong>\u00a0(divide under specific conditions).<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2>Types of Stem Cells: Embryonic vs Adult Stem Cells<\/h2>\n<figure class=\"table\">\n<table style=\"width: 89.6655%;\">\n<tbody>\n<tr>\n<td style=\"width: 21.3141%;\">\n<p><strong>Feature<\/strong><\/p>\n<\/td>\n<td style=\"width: 33.9744%;\">\n<p><strong>Embryonic Stem Cells<\/strong><\/p>\n<\/td>\n<td style=\"width: 72.4803%;\">\n<p><strong>Adult Stem Cells<\/strong><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 21.3141%;\">\n<p><strong>Potency<\/strong><\/p>\n<\/td>\n<td style=\"width: 33.9744%;\">\n<p><strong>Pluripotent<\/strong>\u00a0(any body cell)<\/p>\n<\/td>\n<td style=\"width: 72.4803%;\">\n<p><strong>Multipotent<\/strong>\u00a0(limited types)<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 21.3141%;\">\n<p><strong>Source<\/strong><\/p>\n<\/td>\n<td style=\"width: 33.9744%;\">\n<p><strong>Embryo (blastocyst stage)<\/strong><\/p>\n<\/td>\n<td style=\"width: 72.4803%;\">\n<p><strong>Mature tissues<\/strong>\u00a0(e.g., bone marrow)<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 21.3141%;\">\n<p><strong>Growth in lab<\/strong><\/p>\n<\/td>\n<td style=\"width: 33.9744%;\">\n<p>Can be\u00a0<strong>easily cultured<\/strong><\/p>\n<\/td>\n<td style=\"width: 72.4803%;\">\n<p><strong>Difficult to isolate &amp; expand<\/strong><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 21.3141%;\">\n<p><strong>Ethical concerns<\/strong><\/p>\n<\/td>\n<td style=\"width: 33.9744%;\">\n<p><strong>High<\/strong><\/p>\n<\/td>\n<td style=\"width: 72.4803%;\">\n<p><strong>Low<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p><strong>Source:\u00a0<\/strong><a href=\"https:\/\/www.thehindu.com\/sci-tech\/trials-demonstrate-safety-of-stem-cell-therapy-for-parkinsons\/article69465072.ece\" target=\"_blank\" rel=\"nofollow noopener\">TH<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Parkinson\u2019s disease is a neurodegenerative disorder that causes the progressive loss of dopamine-producing neurons in the brain.<\/p>\n","protected":false},"author":11,"featured_media":42214,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[194],"class_list":{"0":"post-42213","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"tag-stem-cell-therapy-for-parkinsons-disease","9":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/42213","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=42213"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/42213\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/42214"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=42213"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=42213"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=42213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}