{"id":46177,"date":"2025-04-25T11:50:59","date_gmt":"2025-04-25T06:20:59","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=46177"},"modified":"2025-05-28T15:43:16","modified_gmt":"2025-05-28T10:13:16","slug":"human-gene-therapy-trial-for-haemophilia","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/human-gene-therapy-trial-for-haemophilia\/","title":{"rendered":"Human Gene Therapy Trial for Haemophilia"},"content":{"rendered":"<h2>Human Gene Therapy Trial for Haemophilia Latest News<\/h2>\n<p>BRIC-inStem, Bengaluru, has successfully conducted India\u2019s first-in-human gene therapy trial for Haemophilia in collaboration with CMC Vellore.<\/p>\n<h2>About Gene Therapy<\/h2>\n<ul>\n<li><strong>Gene therapy<\/strong>\u00a0is a\u00a0<strong>biomedical technique<\/strong>\u00a0that involves\u00a0<strong>modifying or replacing faulty genes<\/strong>\u00a0in a person\u2019s cells to\u00a0<strong>treat or prevent diseases<\/strong>.<\/li>\n<li>The primary objective is to\u00a0<strong>introduce a functional gene<\/strong>\u00a0to compensate for a\u00a0<strong>mutated or disease-causing gene<\/strong>.<\/li>\n<li>Gene therapy approaches include:\n<ul>\n<li><strong>Replacing<\/strong>\u00a0a mutated gene with a\u00a0<strong>healthy copy<\/strong>.<\/li>\n<li><strong>Inactivating<\/strong>\u00a0a malfunctioning gene.<\/li>\n<li><strong>Introducing<\/strong>\u00a0a completely new gene into the body.<\/li>\n<\/ul>\n<\/li>\n<li>Unlike conventional medicines,\u00a0<strong>gene therapy targets the root genetic causes inside cells<\/strong>, rather than just addressing symptoms.<\/li>\n<li><strong>Current clinical trials<\/strong>\u00a0focus on both\u00a0<strong>inherited and acquired disorders<\/strong>, using methods such as:\n<ul>\n<li><strong>Ex vivo<\/strong>\u00a0modification of\u00a0<strong>hematopoietic stem cells<\/strong>\u00a0and\u00a0<strong>T-lymphocytes<\/strong>.<\/li>\n<li><strong>In vivo<\/strong>\u00a0gene delivery or use of\u00a0<strong>gene-editing reagents<\/strong>\u00a0directly into the patient\u2019s body.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2>About Haemophilia<\/h2>\n<ul>\n<li><strong>Haemophilia<\/strong>\u00a0is a\u00a0<strong>rare genetic bleeding disorder<\/strong>\u00a0where\u00a0<strong>blood clotting is impaired<\/strong>\u00a0due to\u00a0<strong>mutations in genes encoding clotting proteins<\/strong>.<\/li>\n<li>These genes are located on the\u00a0<strong>X chromosome<\/strong>, making\u00a0<strong>males more susceptible<\/strong>.<\/li>\n<li>It affects\u00a0<strong>about 1 in 10,000 people<\/strong>, with\u00a0<strong>India<\/strong>\u00a0having a significant patient load.<\/li>\n<\/ul>\n<h2>About BRIC-inStem<\/h2>\n<ul>\n<li><strong>BRIC-inStem<\/strong>, part of the\u00a0<strong>Biotechnology Research and Innovation Council (BRIC)<\/strong>, integrates 14 autonomous research institutions under one national umbrella.<\/li>\n<li>It has pioneered\u00a0<strong>translational and regenerative research<\/strong>, including:\n<ul>\n<li><strong>Gene therapy<\/strong><\/li>\n<li><strong>Anti-viral germicidal masks<\/strong>\u00a0(developed during COVID-19)<\/li>\n<li><strong>\u2018Kisan Kavach\u2019 pesticide shield<\/strong>\u00a0for farmers<\/li>\n<\/ul>\n<\/li>\n<li><strong>Biosafety Level III Lab<\/strong>\u00a0at BRIC-inStem is essential for studying\u00a0<strong>high-risk pathogens<\/strong>\u00a0under the\u00a0<strong>One Health Mission<\/strong>.<\/li>\n<\/ul>\n<p><strong>Source:\u00a0<\/strong><a href=\"https:\/\/pib.gov.in\/PressReleasePage.aspx?PRID=2124073\" target=\"_blank\" rel=\"nofollow noopener\">PIB<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gene therapy for Haemophilia delivers a working gene to liver cells, enabling the body to produce essential clotting factors and reduce bleeding episodes.<\/p>\n","protected":false},"author":8,"featured_media":46184,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[279,21,22,23],"class_list":{"0":"post-46177","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"tag-human-gene-therapy-trial-for-haemophilia","9":"tag-prelims-pointers","10":"tag-upsc-current-affairs","11":"tag-upsc-prelims-current-affairs","12":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/46177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=46177"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/46177\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/46184"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=46177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=46177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=46177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}