{"id":49859,"date":"2025-06-12T12:00:41","date_gmt":"2025-06-12T06:30:41","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=49859"},"modified":"2025-06-12T12:54:20","modified_gmt":"2025-06-12T07:24:20","slug":"cathepsin-b","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/cathepsin-b\/","title":{"rendered":"Cathepsin B"},"content":{"rendered":"<h2><span style=\"font-weight: 400;\">Cathepsin B Latest News<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Researchers at the National Institute of Animal Biotechnology (NIAB) found that reducing the activity of a cellular protein called \u2018Cathepsin B\u2019 (Cat B) helps preserve the ovarian reserve. <\/span><\/p>\n<h2><span style=\"font-weight: 400;\">About Cathepsin B<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is a <\/span><b>lysosomal cysteine protease.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is primarily localized within subcellular endosomal and <\/span><b>lysosomal compartments<\/b><span style=\"font-weight: 400;\">. It is involved in the turnover of intracellular and extracellular proteins.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is integrated into almost all <\/span><b>lysosome-related processes<\/b><span style=\"font-weight: 400;\">, including protein turnover, degradation,\u00a0 lysosome-mediated cell death, <\/span><b>antigen processing, and apoptosis<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It degrades extracellular matrix proteins like collagen and fibronectin.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Role in Disease:<\/b><span style=\"font-weight: 400;\"> It is involved in <\/span><b>neuropathological and neurodegenerative diseases<\/b><span style=\"font-weight: 400;\"> such as dementia, Alzheimer&#8217;s disease, and traumatic brain injury.<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">What is Ovarian Reserve?<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">This ovarian reserve is the <\/span><b>finite pool of egg cells<\/b><span style=\"font-weight: 400;\"> (oocytes) that female mammals are born with. Unlike sperm, these crucial egg cells cannot be regenerated.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Over time, the quantity and quality of these eggs naturally decline due to factors <\/span><b>like oxidative stress, inflammation and general cellular wear.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">This process <\/span><b>accelerates with age.<\/b><span style=\"font-weight: 400;\"> \u2018Cat B,\u2019 a protein-degrading enzyme, seems to be a key driver of this decline.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">By lowering its levels, we may be able to delay egg loss, effectively extending fertility naturally.<\/span><b><\/b><\/li>\n<\/ul>\n<p><b>Source:<\/b> <a href=\"https:\/\/www.thehindu.com\/sci-tech\/science\/scientists-uncover-molecular-clue-to-slow-down-reproductive-aging\/article69678937.ece\" target=\"_blank\" rel=\"nofollow noopener\">TH<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cathepsin B is a lysosomal cysteine protease involved in protein degradation, cell death, and is linked to cancer and neurodegenerative diseases.<\/p>\n","protected":false},"author":8,"featured_media":49874,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[805,21,22,23],"class_list":{"0":"post-49859","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"tag-cathepsin-b","9":"tag-prelims-pointers","10":"tag-upsc-current-affairs","11":"tag-upsc-prelims-current-affairs","12":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/49859","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=49859"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/49859\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/49874"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=49859"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=49859"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=49859"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}