{"id":52367,"date":"2025-12-03T11:08:13","date_gmt":"2025-12-03T05:38:13","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=52367"},"modified":"2025-12-03T13:14:33","modified_gmt":"2025-12-03T07:44:33","slug":"glp-1-drugs","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/glp-1-drugs\/","title":{"rendered":"GLP-1 Drugs"},"content":{"rendered":"<h2><b>GLP-1 Drugs Latest News<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Recently, the World Health Organization has finally issued global guidelines on the use of popular GLP-1 drugs for weight loss.<\/span><\/p>\n<h2><b>About GLP-1 Drugs<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The <\/span><b>Glucagon-like peptide-1<\/b><span style=\"font-weight: 400;\"> (GLP-1) or <\/span><b>GLP-1 receptor agonists<\/b><span style=\"font-weight: 400;\"> are synthetic drugs which are being used for the <\/span><b>treatment of obesity in adults.<\/b><span style=\"font-weight: 400;\">\u00a0\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">These drugs are <\/span><b>mainly injectables,<\/b><span style=\"font-weight: 400;\"> though oral versions are under development.<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>Examples:<\/b><span style=\"font-weight: 400;\"> Two leading GLP-1 drugs are: Semaglutide and Tirzepatide (by Eli Lilly)<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Both have <\/span><b>been introduced in India<\/b><span style=\"font-weight: 400;\"> and are transforming obesity and diabetes treatment.<\/span><\/li>\n<\/ul>\n<h2><b>How Do GLP-1 Drugs Work?<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">These drugs act by:<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>Increasing insulin secretion<\/b><span style=\"font-weight: 400;\"> when glucose is high.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>Inhibiting glucagon release<\/b><span style=\"font-weight: 400;\">, reducing liver glucose output.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>Slowing gastric emptying,<\/b><span style=\"font-weight: 400;\"> preventing sudden spikes in blood sugar.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>Suppressing appetite,<\/b><span style=\"font-weight: 400;\"> making the person feel full sooner.<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3><b>Key Facts about Glucagon-like peptide-1<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">GLP-1 is both an <\/span><b>incretin hormone and a neurotransmitter.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is a naturally occurring gut hormone (incretin) released <\/span><b>after food intake.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is secreted from <\/span><b>the small intestine<\/b><span style=\"font-weight: 400;\"> and from the <\/span><b>hindbrain <\/b><span style=\"font-weight: 400;\">after we eat a meal.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It travels to the pancreas, where it helps to regulate our <\/span><b>blood sugar by increasing insulin and decreasing glucagon.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It works for just a few minutes, so after you eat a <\/span><b>meal and GLP-1 is secreted naturally<\/b><span style=\"font-weight: 400;\">, it gives an immediate effect that lasts maybe 30 minutes.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">GLP-1 also has beneficial effects in many organs, such as the kidney, liver, and cardiovascular system.<\/span><\/li>\n<\/ul>\n<p><b>Source: <\/b><strong><a href=\"https:\/\/www.thehindu.com\/sci-tech\/health\/who-backs-use-of-glp-1-drugs-for-weight-loss-along-with-diet-exercise\/article70350676.ece\" target=\"_blank\" rel=\"nofollow noopener\">TH<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>GLP-1 Drugs are synthetic drugs which are being used for the treatment of obesity in adults. Read more about GLP-1 Drugs, Meaning, Work, Key Facts, Latest News.<\/p>\n","protected":false},"author":8,"featured_media":52272,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[1145,21,22,23],"class_list":{"0":"post-52367","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"tag-glp-1-drugs","9":"tag-prelims-pointers","10":"tag-upsc-current-affairs","11":"tag-upsc-prelims-current-affairs","12":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/52367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=52367"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/52367\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/52272"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=52367"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=52367"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=52367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}