{"id":55780,"date":"2025-07-19T14:59:43","date_gmt":"2025-07-19T09:29:43","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=55780"},"modified":"2025-07-19T15:47:33","modified_gmt":"2025-07-19T10:17:33","slug":"zimislecel-therapy","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/zimislecel-therapy\/","title":{"rendered":"Zimislecel Therapy"},"content":{"rendered":"<h2><b>Zimislecel Therapy Latest News<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">A small clinical trial, published in The New England Journal of Medicine, tested a therapy called zimislecel which can help in restoring insulin in people with type 1 diabetes.<\/span><\/p>\n<h2><b>About Zimislecel Therapy<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is a new allogeneic <\/span><b>stem cell-derived islet cell therapy in which <\/b><span style=\"font-weight: 400;\">islet cells are infused into the liver.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The pancreas contains clusters of cells that produce hormones. These clusters are known as islets.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Scientists made zimislecel by growing islets from <\/span><b>pluripotent stem cells<\/b><span style=\"font-weight: 400;\"> in the lab.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">These are matured into functioning islets and infused into the <\/span><b>hepatic portal vein.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The hope is that these cells will take root, survive, and begin producing insulin from within the body.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Zimislecel has the potential to restore the body\u2019s <\/span><b>ability to regulate glucose levels<\/b><span style=\"font-weight: 400;\"> by restoring pancreatic islet cell function, including glucose-responsive insulin production<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">These lab-grown cells began <\/span><b>producing insulin again<\/b><span style=\"font-weight: 400;\">, improving blood sugar control, preventing dangerous lows, and, in most cases, eliminating the need for insulin.<\/span><\/li>\n<\/ul>\n<h2><b>What is Type 1 Diabetes?<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is a condition in which your <\/span><b>immune system destroys insulin-making cells<\/b><span style=\"font-weight: 400;\"> in your pancreas. These are called beta cells.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">When you have type 1 diabetes, your <\/span><b>body produces very little or no insulin.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It requires daily administration of <\/span><b>insulin to maintain blood glucose<\/b><span style=\"font-weight: 400;\"> levels under control.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is usually <\/span><b>diagnosed in children and young people,<\/b><span style=\"font-weight: 400;\"> so it used to be called juvenile diabetes.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Symptoms include excessive excretion of urine (polyuria), thirst (polydipsia), constant hunger, weight loss, vision changes, and fatigue.<\/span><\/li>\n<\/ul>\n<p><b>Source:<\/b> <a href=\"https:\/\/www.thehindu.com\/sci-tech\/health\/lab-grown-cells-help-restore-insulin-in-people-with-type-1-diabetes\/article69814405.ece\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">TH<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zimislecel Therapy is a new allogeneic stem cell-derived islet cell therapy in which islet cells are infused into the liver.<\/p>\n","protected":false},"author":24,"featured_media":55813,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[1669],"class_list":{"0":"post-55780","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"tag-zimislecel-therapy","9":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/55780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=55780"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/55780\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/55813"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=55780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=55780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=55780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}