{"id":55894,"date":"2025-07-20T13:12:48","date_gmt":"2025-07-20T07:42:48","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=55894"},"modified":"2025-07-21T14:39:03","modified_gmt":"2025-07-21T09:09:03","slug":"bioemu","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/bioemu\/","title":{"rendered":"BioEmu"},"content":{"rendered":"<h2><b>BioEmu Latest News<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">A new deep learning system called BioEmu predicts the full range of shapes a protein naturally explores under biological conditions.<\/span><\/p>\n<h2><strong>About BioEmu<\/strong><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Biomolecular Emulator<\/b><span style=\"font-weight: 400;\"> (BioEmu for short) is a generative <\/span><b>deep learning system.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It can <\/span><b>generate<\/b><span style=\"font-weight: 400;\"> thousands of statistically independent samples from the <\/span><b>protein structure<\/b> <b>ensemble <\/b><span style=\"font-weight: 400;\">per hour on a single graphical processing unit<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is a model that samples from the approximated <\/span><b>equilibrium distribution<\/b><span style=\"font-weight: 400;\"> of structures for a <\/span><b>protein monomer<\/b><span style=\"font-weight: 400;\">, given its amino acid sequence.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Developed by:<\/b><span style=\"font-weight: 400;\"> It is <\/span><b>developed by Microsoft<\/b><span style=\"font-weight: 400;\"> and researchers at Rice University in the US and Freie Universit\u00e4t in Germany.<\/span><\/li>\n<\/ul>\n<h2><b>Working of BioEmu<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It <\/span><b>predicts the full range of shapes a protein<\/b><span style=\"font-weight: 400;\"> naturally explores under biological conditions.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It promises to be faster and cheaper than classical approaches at predicting protein function<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It allows <\/span><b>high-resolution<\/b><span style=\"font-weight: 400;\"> protein flexibility modelling at scale, unlike slower, more classical approaches like <\/span><b>molecular dynamics (MD) which is slow and costly.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It captures large shape changes in enzymes, local unfolding that switches proteins on or off, and fleeting cryptic pockets, temporary crevices that can serve as drug docking sites, like in the cancer-linked protein Ras.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It predicts 83% of large shifts and 70-81% of small changes accurately, including open and closed forms of a vital enzyme called adenylate kinase.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It also handled <\/span><b>hard to predict proteins<\/b><span style=\"font-weight: 400;\"> that don\u2019t have a fixed 3D structure and how <\/span><b>mutations affect protein stability.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It quickly generates snapshots of all the stable shapes a protein is likely to adopt. It can <\/span><b>produce thousands of these structures<\/b><span style=\"font-weight: 400;\"> in minutes to hours on a single GPU.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">BioEmu <\/span><b>can\u2019t model cell walls<\/b><span style=\"font-weight: 400;\">, drug molecules, <\/span><b>pH changes<\/b><span style=\"font-weight: 400;\"> or show prediction reliability like AlphaFold and also can\u2019t handle <\/span><b>temperature shifts, membranes<\/b><span style=\"font-weight: 400;\">, and other conditions.<\/span><\/li>\n<\/ul>\n<p><b>Source: <\/b><a href=\"https:\/\/www.thehindu.com\/sci-tech\/science\/bioemu-reveals-protein-choreography-in-biological-conditions\/article69810588.ece\" target=\"_blank\" rel=\"nofollow noopener\"><b>TH<\/b><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>BioEmu can generate thousands of statistically independent samples from the protein structure ensemble per hour on a single graphical processing unit.<\/p>\n","protected":false},"author":24,"featured_media":56051,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[1681,21,22,23],"class_list":{"0":"post-55894","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"tag-bioemu","9":"tag-prelims-pointers","10":"tag-upsc-current-affairs","11":"tag-upsc-prelims-current-affairs","12":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/55894","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=55894"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/55894\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/56051"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=55894"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=55894"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=55894"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}