{"id":56178,"date":"2025-09-12T09:59:59","date_gmt":"2025-09-12T04:29:59","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=56178"},"modified":"2025-09-12T15:01:13","modified_gmt":"2025-09-12T09:31:13","slug":"adfalcivax-vaccine","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/adfalcivax-vaccine\/","title":{"rendered":"AdFalciVax Vaccine"},"content":{"rendered":"<h2><b>AdFalciVax Vaccine Latest News<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Recently, the Indian Council of Medical Research (ICMR) has granted non-exclusive rights for its multi-stage malaria vaccine, AdFalciVax, to five pharmaceutical companies.<\/span><\/p>\n<h2><b>About AdFalciVax Vaccine<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is India\u2019s first <\/span><b>indigenous multi-stage malaria recombinant vaccine<\/b><span style=\"font-weight: 400;\"> developed by the Regional Medical Research Centre (RMRC), Bhubaneswar, under the ICMR.<\/span><\/li>\n<\/ul>\n<h2><b>Key Feature of the Vaccine<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The vaccine is designed to prevent <\/span><b>Plasmodium falciparum infection<\/b><span style=\"font-weight: 400;\"> in individuals and reduce community transmission.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Plasmodium falciparum is the <\/span><b>deadliest malaria parasite<\/b><span style=\"font-weight: 400;\">, difficult to control and responsible for widespread devastation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">AdFalciVax targets the <\/span><b>parasite before it enters the bloodstream,<\/b><span style=\"font-weight: 400;\"> stopping the infection at the transmission stage<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The vaccine uses <\/span><b>Lactococcus lactis,<\/b><span style=\"font-weight: 400;\"> a genetically engineered food-grade bacterial host, as its core technology<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It delivers a <\/span><b>dual-antigen approach combining<\/b><span style=\"font-weight: 400;\">: PfCSP (Plasmodium falciparum circumsporozoite protein) to prevent infection and Pfs230 and Pfs48\/45 fusion proteins to block transmission from humans to mosquitoes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">This dual-antigen approach makes AdFalciVax a <\/span><b>multi-functional vaccine<\/b><span style=\"font-weight: 400;\">, aimed at both protecting individuals and halting the spread of malaria.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pre-clinical validation was carried out in collaboration with\u00a0 ICMR\u2013National Institute of Malaria Research (ICMR-NIMR)and National Institute of Immunology (NII), Delhi, under the Department of Biotechnology.<\/span><\/li>\n<\/ul>\n<p><b>Source:<\/b> <a href=\"https:\/\/www.business-standard.com\/industry\/agriculture\/icmr-malaria-vaccine-adfalcivax-licence-companies-salmonella-125091000446_1.html\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">BS<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>AdFalciVax Vaccine is a recombinant vaccine, meaning parts of the genes that encode for targets are inserted into a cell, the target proteins are expressed, and then used to trigger an immune response. Read more about AdFalciVax Vaccine, Advantages, Latest News<\/p>\n","protected":false},"author":24,"featured_media":56224,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[1727,21,22,23],"class_list":{"0":"post-56178","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"tag-adfalcivax-vaccine","9":"tag-prelims-pointers","10":"tag-upsc-current-affairs","11":"tag-upsc-prelims-current-affairs","12":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/56178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=56178"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/56178\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/56224"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=56178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=56178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=56178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}