{"id":77423,"date":"2025-12-11T13:55:23","date_gmt":"2025-12-11T08:25:23","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=77423"},"modified":"2025-12-12T15:44:23","modified_gmt":"2025-12-12T10:14:23","slug":"glowcas9-protein","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/glowcas9-protein\/","title":{"rendered":"GlowCas9 Protein"},"content":{"rendered":"<h2><b>GlowCas9 Protein Latest News<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Recently, scientists from Kolkata based Bose institute have created GlowCas9 protein which can track gene editing.<\/span><\/p>\n<h2><b>About GlowCas9 Protein<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is a <\/span><b>CRISPR protein<\/b><span style=\"font-weight: 400;\"> that lights up while performing gene editing.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is a <\/span><b>bioluminescent version of Cas9<\/b><span style=\"font-weight: 400;\"> that glows inside cells.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Structure: <\/b><span style=\"font-weight: 400;\">GlowCas9 is created <\/span><b>by fusing Cas9<\/b><span style=\"font-weight: 400;\"> with a split <\/span><b>nano-luciferase enzyme<\/b><span style=\"font-weight: 400;\"> derived from <\/span><b>deep-sea shrimp proteins.<\/b><\/li>\n<\/ul>\n<h2><b>Properties of GlowCas9 Protein<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The GlowCas9 is <\/span><b>very stable and maintains<\/b><span style=\"font-weight: 400;\"> its structure and <\/span><b>activity at higher temperatures<\/b><span style=\"font-weight: 400;\"> compared to the conventional enzyme.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>It glows inside cells,<\/b><span style=\"font-weight: 400;\"> allowing for real-time monitoring of CRISPR operations<\/span><\/li>\n<\/ul>\n<h2><b>Working of GlowCas9 Protein<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The <\/span><b>split nano-luciferase enzyme<\/b><span style=\"font-weight: 400;\"> pieces reconnect when Cas9 folds correctly, producing light<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">This glowing activity <\/span><b>allows scientists to monitor <a href=\"https:\/\/vajiramandravi.com\/current-affairs\/crispr\/\" target=\"_blank\">CRISPR<\/a> operations<\/b><span style=\"font-weight: 400;\"> in living cells, tissues, and even plant leaves\u2014without harming them.<\/span><\/li>\n<\/ul>\n<h2><b>Benefits of GlowCas9 Protein<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It can also increase the <\/span><b>precision of homology-directed repair<\/b><span style=\"font-weight: 400;\"> (HDR).<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>Homology-Directed Repair<\/b><span style=\"font-weight: 400;\"> (HDR) is a <\/span><b>DNA repair process crucial<\/b><span style=\"font-weight: 400;\"> for <\/span><b>fixing hereditary mutations<\/b><span style=\"font-weight: 400;\"> that are linked to genetic diseases like sickle cell anaemia, muscular dystrophy and so on.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">GlowCas9 pioneers the emerging <\/span><b>field of theratracking<\/b><span style=\"font-weight: 400;\"> or visualizing molecular gene therapy in motion.<\/span><\/li>\n<\/ul>\n<p><b>Source: <\/b><strong><a href=\"https:\/\/www.pib.gov.in\/PressReleasePage.aspx?PRID=2201313&amp;reg=3&amp;lang=2\" target=\"_blank\" rel=\"nofollow noopener\">PIB<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>GlowCas9 Protein is a CRISPR protein that lights up while performing gene editing. Read more about GlowCas9 Protein, Properties, Working, Benefits, Latest News.<\/p>\n","protected":false},"author":24,"featured_media":77399,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[4144,21,22,23],"class_list":{"0":"post-77423","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"tag-glowcas9-protein","9":"tag-prelims-pointers","10":"tag-upsc-current-affairs","11":"tag-upsc-prelims-current-affairs","12":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/77423","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=77423"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/77423\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/77399"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=77423"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=77423"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=77423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}