{"id":80519,"date":"2026-01-02T15:01:17","date_gmt":"2026-01-02T09:31:17","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=80519"},"modified":"2026-01-02T15:01:17","modified_gmt":"2026-01-02T09:31:17","slug":"pathgennie","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/pathgennie\/","title":{"rendered":"PathGennie"},"content":{"rendered":"<h2><b>PathGennie Latest News<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Recently, the Ministry of Science and Technology has developed new open-source software called PathGennie.<\/span><\/p>\n<h2><b>About PathGennie<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is a <\/span><b>novel computational framework<\/b><span style=\"font-weight: 400;\"> developed by scientists that can significantly accelerate the simulation of <\/span><b>rare molecular events.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It<\/span> <span style=\"font-weight: 400;\">is <\/span><b>open source software<\/b><span style=\"font-weight: 400;\"> developed for <\/span><b>fast tracking of drug discovery<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is aimed at <\/span><b>fast-tracking the drug discovery<\/b><span style=\"font-weight: 400;\"> process by accurately tracking molecular unbinding pathways.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It addresses a long-standing challenge in <\/span><b>molecular simulations<\/b><span style=\"font-weight: 400;\"> \u2014 accurately modelling how drug molecules detach from their target proteins.<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">This process, known as <\/span><b>ligand unbinding,<\/b><span style=\"font-weight: 400;\"> plays a key role in determining a drug\u2019s \u201cresidence time\u201d, which is often more relevant to therapeutic effectiveness than binding strength alone.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It predicts the <\/span><b>potential drugs unbind<\/b><span style=\"font-weight: 400;\"> from their protein targets without the artificial distortions commonly used in standard methods.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It mimics <\/span><b>natural selection<\/b><span style=\"font-weight: 400;\"> on a microscopic scale <\/span><b>instead of forcing the molecule to move.<\/b><\/li>\n<\/ul>\n<h2><b>Features of PathGennie<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It <\/span><b>captures rare molecular<\/b><span style=\"font-weight: 400;\"> events without artificial acceleration.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It generates multiple competitive unbinding pathways.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It estimates residence time of drug molecules.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It eliminates bias introduced by external force-based simulations<\/span><\/li>\n<\/ul>\n<h2><b>Potential Applications of PathGennie<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It addresses problems such as c<\/span><b>hemical reactions, catalytic processes, <\/b><span style=\"font-weight: 400;\">phase transitions, or self-assembly phenomena.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is also <\/span><b>compatible with modern machine-learning techniques<\/b><span style=\"font-weight: 400;\"> which ensures integration into <\/span><b>diverse simulation pipelines.<\/b><\/li>\n<\/ul>\n<p><b>Source: <\/b><strong><a href=\"https:\/\/www.newsonair.gov.in\/ministry-of-science-and-technology-develops-software-pathgennie-for-fast-tracking-of-drug-discovery\/\" target=\"_blank\" rel=\"nofollow noopener\">News On Air<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PathGennie is a novel computational framework developed by scientists that can significantly accelerate the simulation of rare molecular events. Read more about PathGennie Framework, Features, Applications, Latest News.<\/p>\n","protected":false},"author":24,"featured_media":80560,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[4503],"class_list":{"0":"post-80519","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"tag-pathgennie","9":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/80519","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=80519"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/80519\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/80560"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=80519"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=80519"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=80519"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}