{"id":82942,"date":"2026-01-17T13:17:20","date_gmt":"2026-01-17T07:47:20","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=82942"},"modified":"2026-01-17T14:51:17","modified_gmt":"2026-01-17T09:21:17","slug":"intrinsically-disordered-proteins","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/intrinsically-disordered-proteins\/","title":{"rendered":"Intrinsically Disordered Proteins"},"content":{"rendered":"<h2><b>Intrinsically Disordered Proteins Latest News<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Researchers have developed a deep-learning tool named Disobind that can predict how intrinsically disordered proteins (IDP) latch on to their binding partners.<\/span><\/p>\n<h2><b>About Intrinsically Disordered Proteins<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Intrinsically disordered proteins are <\/span><b>defined as proteins or regions of proteins<\/b><span style=\"font-weight: 400;\"> that <\/span><b>lack a fixed <\/b><span style=\"font-weight: 400;\">or ordered three-<\/span><b>dimensional structure<\/b><span style=\"font-weight: 400;\"> under biological conditions.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Other Names:<\/b><span style=\"font-weight: 400;\"> Also called natively unfolded or <\/span><b>intrinsically unstructured proteins.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">These are important for <\/span><b>cellular signaling and regulation.<\/b><\/li>\n<\/ul>\n<h2><b>Functions of<\/b> <b>Intrinsically Disordered Proteins<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">They are shape shifting molecules <\/span><b>vital to cellular communication<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">They don\u2019t <\/span><b>form a fixed structure.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">They guide <\/span><b>signalling networks.<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">They help proteins <\/span><b>move and find partners within the cell<\/b><span style=\"font-weight: 400;\">, regulate which genes are switched on or off,<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">IDP supports <\/span><b>protein folding and quality control<\/b><span style=\"font-weight: 400;\">, and assembles flexible cellular <\/span><b>hubs called condensates.<\/b><\/li>\n<\/ul>\n<h3><b>Key Facts about Disobind Tool<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is developed by the researchers of <\/span><b>National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research, Bengaluru.<\/b><\/li>\n<\/ul>\n<h3><b>Features of Disobind Tool<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is <\/span><b>open-source<\/b><span style=\"font-weight: 400;\"> and freely available for researchers worldwide.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It <\/span><b>analyses the protein sequences<\/b><span style=\"font-weight: 400;\"> and uses <\/span><b>protein language models<\/b><span style=\"font-weight: 400;\"> (a form of AI trained on millions of known protein sequences).<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>No structural info needed:<\/b><span style=\"font-weight: 400;\"> It does <\/span><b>not require any structural information<\/b><span style=\"font-weight: 400;\"> or sequence alignments, making it super convenient.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>High accuracy<\/b><span style=\"font-weight: 400;\">: Disobind outperformed popular tools like AlphaFold-multimer and AlphaFold3 in tests on new protein pairs.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Disobind delivered consistently higher accuracy when tested on new protein pairs it had not seen before.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Applications of the tool could span from <\/span><b>disease biology to drug design.<\/b><\/li>\n<\/ul>\n<p><b>Source: <\/b><strong><a href=\"https:\/\/www.thehindu.com\/news\/cities\/bangalore\/researchers-develop-ai-tool-to-predict-how-shapeshifting-proteins-connect-inside-cells\/article70509429.ece\/amp\/\" target=\"_blank\" rel=\"nofollow noopener\">TH<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Intrinsically Disordered Proteins are defined as proteins or regions of proteins that lack a fixed or ordered three-dimensional structure under biological conditions.<\/p>\n","protected":false},"author":24,"featured_media":82967,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[4784,21,22,23],"class_list":{"0":"post-82942","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"tag-intrinsically-disordered-proteins","9":"tag-prelims-pointers","10":"tag-upsc-current-affairs","11":"tag-upsc-prelims-current-affairs","12":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/82942","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=82942"}],"version-history":[{"count":0,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/82942\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/82967"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=82942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=82942"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=82942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}