{"id":93230,"date":"2026-03-17T13:16:49","date_gmt":"2026-03-17T07:46:49","guid":{"rendered":"https:\/\/vajiramandravi.com\/current-affairs\/?p=93230"},"modified":"2026-03-17T13:16:49","modified_gmt":"2026-03-17T07:46:49","slug":"hutchinson-gilford-progeria-syndrome","status":"publish","type":"post","link":"https:\/\/vajiramandravi.com\/current-affairs\/hutchinson-gilford-progeria-syndrome\/","title":{"rendered":"Hutchinson-Gilford Progeria Syndrome (HGPS)"},"content":{"rendered":"<h2><b>Hutchinson-Gilford Progeria Syndrome (HGPS) Latest News<\/b><\/h2>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">U.S.-based Sentynl Therapeutics (part of Zydus Lifesciences) recently signed a deal with South Korea&#8217;s PRG S&amp;T to develop Progerinin, a pill aimed at treating Hutchinson-Gilford progeria syndrome (HGPS).<\/span><\/p>\n<h2><b>About Hutchinson-Gilford Progeria Syndrome (HGPS)<\/b><\/h2>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Progeria, also known as HGPS, is an <\/span><b>extremely rare genetic disease <\/b><span style=\"font-weight: 400;\">that causes <\/span><b>rapid aging in children.<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Progeria is extremely rare. It occurs in<\/span><b> 1 in every 4 million live births <\/b><span style=\"font-weight: 400;\">worldwide.<\/span><\/li>\n<li style=\"text-align: justify;\"><b>What Causes Progeria?<\/b>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">A <\/span><b>genetic mutation in the LMNA gene<\/b><span style=\"font-weight: 400;\"> causes progeria.\u00a0 The LMNA gene is <\/span><b>responsible for making <\/b><span style=\"font-weight: 400;\">a protein called<\/span><b> lamin A.<\/b><\/li>\n<li style=\"text-align: justify;\"><b>Lamin A<\/b><span style=\"font-weight: 400;\"> is an<\/span> <span style=\"font-weight: 400;\">important part of the structural scaffolding that <\/span><b>holds the nucleus of each cell in your body together.<\/b><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">A <\/span><b>tiny mutation<\/b><span style=\"font-weight: 400;\"> in the LMNA gene <\/span><b>cause<\/b><span style=\"font-weight: 400;\">s it to create an<\/span><b> irregular form<\/b><span style=\"font-weight: 400;\"> of the <\/span><b>lamin A protein called progerin.\u00a0<\/b><\/li>\n<li style=\"text-align: justify;\"><b>Progerin <\/b><span style=\"font-weight: 400;\">takes the place of the lamin A and <\/span><b>makes the nuclei<\/b><span style=\"font-weight: 400;\"> of your cells <\/span><b>unstable, slowly damaging <\/b><span style=\"font-weight: 400;\">them<\/span><b>.<\/b><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">This leads to the<\/span><b> early death of every cell <\/b><span style=\"font-weight: 400;\">in your body, which causes the process of<\/span><b> premature aging.<\/b><\/li>\n<li style=\"text-align: justify;\"><b>Almost all cases <\/b><span style=\"font-weight: 400;\">of progeria occur as a <\/span><b>new, spontaneous mutation <\/b><span style=\"font-weight: 400;\">in the LMNA gene. This means there\u2019s <\/span><b>no biological family histor<\/b><span style=\"font-weight: 400;\">y of the disease.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"text-align: justify;\"><b>Newborns <\/b><span style=\"font-weight: 400;\">with the disorder appear to be healthy at birth but usually start to show <\/span><b>signs of premature aging<\/b><span style=\"font-weight: 400;\"> during their <\/span><b>first one to two years <\/b><span style=\"font-weight: 400;\">of life.\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Their <\/span><b>growth rate slows<\/b><span style=\"font-weight: 400;\"> and they <\/span><b>don\u2019t gain weight<\/b><span style=\"font-weight: 400;\"> as expected.\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">This condition <\/span><b>does not affect intellectual development<\/b><span style=\"font-weight: 400;\"> or the <\/span><b>development of motor skills<\/b><span style=\"font-weight: 400;\"> such as sitting, standing, and walking.\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">However, their rapid aging <\/span><b>causes distinct physical characteristics,<\/b><span style=\"font-weight: 400;\"> including:<\/span>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Hair loss (<\/span><b>baldness<\/b><span style=\"font-weight: 400;\">).<\/span><\/li>\n<li style=\"text-align: justify;\"><b>Prominent eyes<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Aged, <\/span><b>wrinkled skin<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">A thin, beaked nose.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Disproportionately small face compared to head size.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Loss of fat under the skin.<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Progeria is <\/span><b>always fatal.<\/b><span style=\"font-weight: 400;\"> The <\/span><b>average age of death is 14.5 years<\/b><span style=\"font-weight: 400;\">, although some adults with progeria will live into their early 20s.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Death most often <\/span><b>occurs as a result <\/b><span style=\"font-weight: 400;\">of complications of <\/span><b>severe atherosclerosis.\u00a0<\/b>\n<ul>\n<li style=\"text-align: justify;\"><b>Atherosclerosis <\/b><span style=\"font-weight: 400;\">occurs when <\/span><b>plaque builds up within <\/b><span style=\"font-weight: 400;\">the <\/span><b>walls of your arteries. <\/b><span style=\"font-weight: 400;\">This makes them less elastic and, therefore, stiffer.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-weight: 400;\">This condition greatly increases the chances of having a <\/span><b>heart attack or stroke at a young age.<\/b><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong>Source: <a href=\"https:\/\/www.newsbytesapp.com\/news\/business\/zydus-lifesciences-sentynl-to-fully-own-progeria-drug-progerinin\/tldr\" target=\"_blank\" rel=\"nofollow noopener\">NB<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hutchinson-Gilford Progeria Syndrome is an extremely rare genetic disease that causes rapid aging in children. Read more about Hutchinson-Gilford Progeria Syndrome, Causes, Treatment, Latest News.<\/p>\n","protected":false},"author":23,"featured_media":93237,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[6139],"class_list":{"0":"post-93230","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-upsc-prelims-current-affairs","8":"tag-hutchinson-gilford-progeria-syndrome","9":"no-featured-image-padding"},"acf":[],"_links":{"self":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/93230","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=93230"}],"version-history":[{"count":5,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/93230\/revisions"}],"predecessor-version":[{"id":93261,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/posts\/93230\/revisions\/93261"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media\/93237"}],"wp:attachment":[{"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=93230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=93230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vajiramandravi.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=93230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}