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Indian Veterinary Research Institute (IVRI) has recently demanded a ban on using aceclofenac in cattle after a new study showed that the drug metabolises into diclofenac in water buffaloes — as it does in cows.

About Aceclofenac:

  • Aceclofenac is the prodrug of the non‐steroidal anti‐inflammatory drug (NSAID) diclofenac.
  • Aceclofenac in water buffaloes poses the same threat to vultures as it is a pro-drug of diclofenac.
  • Aceclofenac turns into diclofenac soon after it enters the livestock.
  • Vulture Action Plan 2020-2025 also mentions the aceclofenac as ‘toxic’, along with other drugs like nimesulide and ketoprofen.


  • Diclofenac is an anti-inflammatory drug.
  • It was banned for veterinary use by the Government of India in 2006.
  • It was found to be the main cause of a dramatic decline (99 per cent) of the vulture population across Asia.
  • The drug caused accidental poisoning in raptors after they fed on carcasses of cattle injected with it.

Source : Down to Earth