What is AgeXtend?
11-12-2024
10:30 AM
1 min read

Overview:
Researchers at IIIT-Delhi have developed AgeXtend, an artificial intelligence (AI)-powered platform designed to discover molecules that could slow down ageing and promote healthier lives.
About AgeXtend:
- It is an artificial intelligence (AI)-powered platform designed to discover molecules that could slow down ageing and promote healthier lives.
- It was developed by researchers at the Indraprastha Institute of Information Technology Delhi (IIIT-Delhi).
- AgeXtend utilises bioactivity data from existing geroprotectors-substances that slow ageing-to predict new molecules with similar properties.
- Its AI modules evaluate geroprotective potential, assess toxicity, and identify target proteins and mechanisms of action, ensuring both accuracy and safety in the discovery process.
- The researchers tested AgeXtend by excluding well-known compounds like metforminand taurine, molecules already known to extend lifespan, and found that the platform could still predict their benefits.
- AgeXtend also screened more than 1.1 billion compounds and identified promising candidates validated through experiments on yeast, Caenorhabditis elegans (a nematode), and human cell models.
- The research also explored AgeXtend's ability to analyze natural compounds found in the human microbiome, tiny organisms living in our bodies, and their role in controlling cell ageing.

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News: Indian AI screens 1.1 billion molecules, makes anti-ageing breakthrough