GEMCOVAC –OM Vaccine

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Overview:

Recently, India’s first indigenous mRNA vaccine for the Omicron variant, GEMCOVAC-OM was approved under emergency use guidelines by the Drug Controller General of India.

About GEMCOVAC –OM Vaccine:

  • It was developed using the indigenous platform technology by Gennova Biopharmaceuticals Ltd. and supported under the Mission COVID Suraksha, implemented by Biotechnology Industry Research Assistance Council (BIRAC).
  • It is a thermo-stable vaccine, which does not require ultra-cold chain infrastructure used for other approved mRNA-based vaccines, making it easy for deployment pan India.
  • It is delivered intra-dermally using a needle-free injection device system.
  • When administered intradermally in participants as a booster, it generated significantly higher immune responses.
  • The clinical outcome demonstrates the need for variant-specific vaccines for desired immune response.

Key facts about BIRAC

  • It is a not-for-profit Section 8, Schedule B, Public Sector Enterprise, set up by the Department of Biotechnology (DBT), Government of India,
  • It is an Interface Agency to strengthen and empower emerging Biotech enterprises to undertake strategic research and innovation, addressing nationally relevant product development needs.

What is mRNA vaccine?

  • It contains messenger RNA (mRNA), a single-stranded RNA molecule that complements DNA.
  • It is created in the nucleus when DNA is transcribed by RNA polymerase to create pre-mRNA

 


Q1) What is cell nucleus?

In biology, the nucleus is a membrane-bound organelle found in eukaryotic cells. It is often referred to as the "control center" of the cell because it houses the genetic material and regulates cellular activities.

Source: Omicron-specific mRNA-based Booster vaccine developed using the indigenous platform technology