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The Technology Development Board (TDB) has penned an agreement with two companies and has sanctioned a grant of ₹75 Lakhs towards the project "ANAGRANINF for the development of a Novel Class of Antibiotics Against Gram-Negative Bacterial-Infections.

About Project ANAGRANINF

  • The primary objective of this project is to develop a novel lead compound, particularly an antibiotic, adept at inhibiting the FabI enzyme and combatting critical gram-negative pathogens.

What is a Gram-negative bacteria?

  • They have a much thinner peptidoglycan cell wall, but in addition they have an outer membrane containing lipopolysaccharides surrounding the cell and are consequently termed diderms.
  • These bacteria have built-in abilities to find new ways to be resistant and can pass along genetic materials that allow other bacteria to become drug-resistant as well. 
  • It causes infections including pneumonia, bloodstream infections, wound or surgical site infections, and meningitis in healthcare settings.
  • Gram-negative bacteria are resistant to multiple drugs and are increasingly resistant to most available antibiotics.
  • Examples: Bacteria include enterobacter species, salmonella species and pseudomonas species.

Key facts about the Technology Development Board

  • It is a statutory body constituted under the Technology Development Board Act, 1995.
  • It aims to promote the development and commercialization of indigenous technology and the adaptation of imported technology for wider application.
  • The board consists of 11 Board members.
  • It provides equity capital or loans to industrial concerns and financial assistance to research and development institutions. 
  • The Fund has been receiving grants from the Government of India out of the cess collections from the industrial concerns under the provisions of the Research and Development Cess Act, 1986, as amended in 1995.

Q1) What are Bacteria?

These are microscopic single-celled prokaryotic organisms that play a crucial role in the ecosystem and have a significant impact on human health. Bacteria can be found all over the world, including the top of the mountains or the deeper trenches in the oceans. 

Source: Technology Development Board -Department of Science & Technology provides M/s Peptris Technologies Pvt. Ltd. and Foundation for Neglected Disease Research (FNDR) with ₹75 Lakhs Grant for Innovative Antibiotic Development Project