Vascular Endothelial Growth Factor

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Overview:

Recently, scientists from the Institute of Advanced Study in Science and Technology said that fluorescent carbon nanomaterial-based immunosensor from natural sources can help in the detection of the V

About Vascular Endothelial Growth Factor:

  • It is a factor that promotes angiogenesis or the formation of new blood vessels, which involves migration, growth, and differentiation of endothelial cells that line the inside wall of blood vessels.
  • It is upregulated in many tumors and hence gives indications of the probability of cancers.
  • Scientists fabricated an immunosensor based on the fluorescence phenomenon of biogenic carbon quantum dots, a new class of carbon nanomaterials, for the detection of the biomarker Vascular Endothelial Growth Factor (VEGF).
  • The sandwiched immunosensor was fabricated using a fluorescent nanomaterial (Carbon quantum dots) synthesized from a natural source, employing a green microwave-assisted method.
  • This was followed by conjugating with a detection antibody, human immunoglobulin G (IgG).

What is Endothelium?

  • The endothelium is a monolayer of endothelial cells and constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system.
  • The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone.
  • It is a major factor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and endocrine organ. 

 


 Q1) What is the role of platelet?

Platelets are tiny blood cells that help our body form clots to stop bleeding. If one of our blood vessels gets damaged then platelets rush to the site of damage and form a clot to fix the damage.

Source: Fluorescent carbon nanomaterial-based immunosensor from natural sources can help early detection of cancer