What is Abaucin?

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Recently, researchers have used machine learning to identify a potential new antibiotic called abaucin, which targets the highly resistant Acinetobacter baumannii bacteria.

About Abaucin:

  • It is known to compromise the normal function of a protein called CCR2. 
  • It appears to work by disrupting lipoprotein trafficking in A. baumannii.
  • Based on genetic studies, the researchers believe that abaucin could be preventing lipoprotein produced inside the bacteria from moving to the outer membrane.
  • Abaucin is also “species-selective”, it only disrupts the growth of A. baumannii, not other Gram-negative bacteria.

What is an Acinetobacter baumanni?

  • It is a Gram-negative bacteria, which means it has a protective outer membrane that allows it to resist antibiotics.
  • It has been associated with hospital-acquired infections in India.
  • It was acknowledged to be a “red alert” pathogen because of its exceptional ability to develop resistance to all currently available antibiotics.


Q1) What is Gram-negative bacteria?

Gram-negative bacteria are a group of bacteria that are characterized by their response to the Gram staining technique, which is a method used to classify bacteria into two broad categories: Gram-positive and Gram-negative. Gram-negative bacteria have a unique cell wall structure that distinguishes them from Gram-positive bacteria.

Source: Explained | Abaucin, the potential new antibiotic found with machine-learning