What is IITR00693?

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What is IITR00693? Blog Image


Researchers at the Indian Institute of Technology, Roorkee, recently discovered a new antibacterial molecule -- IITR00693, that could help fight against drug-resistant infections.

About IITR00693:

  • It is a novel antibacterial small molecule.
  • It has shown potent antibacterial activity against a wide range of Gram-positive and Gram-negative bacteria, including some of the most problematic drug-resistant strains.
  • IITR00693 acts like a dual sword; it not only strikes down the most stubborn bacteria but also prevents the emergence of resistance, ensuring that it remains effective for generations to come.
  • It enhances the activity of antibiotics that are used in the treatment of bacterial infections.
  • It potentiates the activity of polymyxins against two notorious multidrug-resistant skin-infecting pathogens, Staphylococcus aureus, and Pseudomonas aeruginosa.


What are Gram-positive and Gram-negative bacteria?

  • Gram-positive bacteria:
    • They show blue or purple after gram-staining in a laboratory test.
    • They have thick peptidoglycan cell walls.
    • They do not have a protective outer membrane.
  • Gram-negative bacteria:
    • They show pink or red on staining.
    • They have thin peptidoglycan cell walls.
    • They have an outer membrane.  
    • They release different toxins and affect the body in different ways.


Q1) What are antibiotics?

Antibiotics are medicines that fight bacterial infections in people and animals. They work by killing the bacteria or by making it hard for the bacteria to grow and multiply.

Source: Research team at IIT-Roorkee discovers new antibacterial molecule