RK-251 Drug Latest News
Recently, the Ministry of Science and Technology informed, about a new smart drug named RK-251 that can replace traditional chemotherapy.Â
About RK-251 Drug
- It is a smart cancer drug designed to activate primarily in cancer cells and does not harm healthy cells.
- It is developed in collaboration with Dr. Asis Bala from the Institute of Advanced Study in Science and Technology (IASST) and Dr. K.P. Bhabak from the Indian Institute of Technology-Guwahati.
- Working Mechanism
- When RK-251 enters a cancer cell with high reactive oxygen species (ROS) levels, these molecules trigger the drug’s activation, releasing an anticancer compound called NBDHEX.
- NBDHEX blocks target proteins that many cancer cells use to survive and resist treatment.Â
- The idea is to keep RK-251 relatively inactive in normal tissues and activate its anticancer action inside cancer cells.
- It exhibited strong activity against aggressive triple-negative breast cancer cells, with much less effect on healthy cells.
- It displayed the desired fluorescence in the presence of reactive oxygen species.
- The fluorescence response also provides an indication that the drug is being activated in an ROS-rich environment, supporting the underlying mechanism of the targeted approach.
Source: News On Air
RK-251 Drug FAQs
Q1: RK-251 is a drug candidate developed for the treatment of which disease?
Ans: Cancer
Q2: What is the key advantage of RK-251 over conventional chemotherapy?
Ans: It attacks only cancer cells and spares healthy cells