| Nobel Prize winners in Physiology or Medicine (1901-2025) |
| S. No. |
Year |
Name |
Contribution |
|
1
|
2025
|
Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi
|
Discoveries concerning peripheral immune tolerance
|
|
2
|
2024
|
Victor Ambros, Gary Ruvkun
|
Discovery of microRNA and its role in post-transcriptional gene regulation
|
|
3
|
2023
|
Katalin Karikó, Drew Weissman
|
Discoveries concerning nucleoside base modifications enabling mRNA COVID-19 vaccines
|
|
4
|
2022
|
Svante Pääbo
|
Discoveries concerning genomes of extinct hominins and human evolution
|
|
5
|
2021
|
David Julius, Ardem Patapoutian
|
Discoveries of receptors for temperature and touch
|
|
6
|
2020
|
Harvey J. Alter, Michael Houghton, Charles M. Rice
|
Discovery of Hepatitis C virus
|
|
7
|
2019
|
William G. Kaelin Jr, Sir Peter J. Ratcliffe, Gregg L. Semenza
|
Discoveries of how cells sense and adapt to oxygen availability
|
|
8
|
2018
|
James P. Allison, Tasuku Honjo
|
Discovery of cancer therapy by inhibition of negative immune regulation
|
|
9
|
2017
|
Jeffrey C. Hall, Michael Rosbash, Michael W. Young
|
Discoveries of molecular mechanisms controlling the circadian rhythm
|
|
10
|
2016
|
Yoshinori Ohsumi
|
Discoveries of mechanisms for autophagy
|
|
11
|
2015
|
William C. Campbell, Satoshi Ōmura, Tu Youyou
|
Discoveries concerning therapies against roundworm infections and Malaria
|
|
12
|
2014
|
John O'Keefe, May-Britt Moser, Edvard I. Moser
|
Discoveries of cells constituting a positioning system in the brain
|
|
13
|
2013
|
James E. Rothman, Randy W. Schekman, Thomas C. Südhof
|
Discoveries of machinery regulating vesicle traffic
|
|
14
|
2012
|
Sir John B. Gurdon, Shinya Yamanaka
|
Discovery that mature cells can be reprogrammed to become pluripotent
|
|
15
|
2011
|
Bruce A. Beutler, Jules A. Hoffmann, Ralph M. Steinman
|
Discoveries on activation of innate immunity and dendritic cells' role in adaptive immunity
|
|
16
|
2010
|
Robert G. Edwards
|
Development of in vitro fertilization
|
|
17
|
2009
|
Elizabeth H. Blackburn, Carol W. Greider, Jack W. Szostak
|
Discovery of how chromosomes are protected by telomeres and telomerase
|
|
18
|
2008
|
Harald zur Hausen, Françoise Barré-Sinoussi, Luc Montagnier
|
Discovery of HPV causing cervical cancer and HIV
|
|
19
|
2007
|
Mario R. Capecchi, Sir Martin J. Evans, Oliver Smithies
|
Discoveries of principles for gene modifications in mice using embryonic stem cells
|
|
20
|
2006
|
Andrew Z. Fire, Craig C. Mello
|
Discovery of RNA interference (gene silencing by double-stranded RNA)
|
|
21
|
2005
|
Barry J. Marshall, J. Robin Warren
|
Discovery of Helicobacter pylori and its role in gastritis and peptic ulcer disease
|
|
22
|
2004
|
Richard Axel, Linda B. Buck
|
Discoveries of odorant receptors and organization of the olfactory system
|
|
23
|
2003
|
Paul C. Lauterbur, Sir Peter Mansfield
|
Discoveries concerning magnetic resonance imaging (MRI)
|
|
24
|
2002
|
Sydney Brenner, H. Robert Horvitz, John E. Sulston
|
Discoveries on genetic regulation of organ development and programmed cell death
|
|
25
|
2001
|
Leland Hartwell, Tim Hunt, Sir Paul Nurse
|
Discoveries of key regulators of the cell cycle
|
|
26
|
2000
|
Arvid Carlsson, Paul Greengard, Eric Kandel
|
Discoveries concerning signal transduction in the nervous system
|
|
27
|
1999
|
Günter Blobel
|
Discovery that proteins have intrinsic signals governing transport and localization
|
|
28
|
1998
|
Robert F. Furchgott, Louis J. Ignarro, Ferid Murad
|
Discoveries concerning nitric oxide as a signalling molecule in the cardiovascular system
|
|
29
|
1997
|
Stanley B. Prusiner
|
Discovery of Prions as a new biological principle of infection
|
|
30
|
1996
|
Peter C. Doherty, Rolf M. Zinkernagel
|
Discoveries concerning specificity of cell-mediated immune defence
|
|
31
|
1995
|
Edward B. Lewis, Christiane Nüsslein-Volhard, Eric F. Wieschaus
|
Discoveries concerning genetic control of early embryonic development
|
|
32
|
1994
|
Alfred G. Gilman, Martin Rodbell
|
Discovery of G-proteins and their role in signal transduction
|
|
33
|
1993
|
Richard J. Roberts, Phillip A. Sharp
|
Discoveries of split genes
|
|
34
|
1992
|
Edmond H. Fischer, Edwin G. Krebs
|
Discoveries concerning reversible protein phosphorylation
|
|
35
|
1991
|
Erwin Neher, Bert Sakmann
|
Discoveries concerning the function of single ion channels in cells
|
|
36
|
1990
|
Joseph E. Murray, E. Donnall Thomas
|
Discoveries concerning organ and cell transplantation in treatment of human disease
|
|
37
|
1989
|
J. Michael Bishop, Harold E. Varmus
|
Discovery of the cellular origin of retroviral oncogenes
|
|
38
|
1988
|
Sir James W. Black, Gertrude B. Elion, George H. Hitchings
|
Discoveries of important principles for drug treatment
|
|
39
|
1987
|
Susumu Tonegawa
|
Discovery of the genetic principle for generation of antibody diversity
|
|
40
|
1986
|
Stanley Cohen, Rita Levi-Montalcini
|
Discoveries of growth factors
|
|
41
|
1985
|
Michael S. Brown, Joseph L. Goldstein
|
Discoveries concerning regulation of cholesterol metabolism
|
|
42
|
1984
|
Niels K. Jerne, Georges J.F. Köhler, César Milstein
|
Theories on immune system specificity and monoclonal antibody production
|
|
43
|
1983
|
Barbara McClintock
|
Discovery of mobile genetic elements
|
|
44
|
1982
|
Sune K. Bergström, Bengt I. Samuelsson, John R. Vane
|
Discoveries concerning prostaglandins and related substances
|
|
45
|
1981
|
Roger W. Sperry, David H. Hubel, Torsten N. Wiesel
|
Discoveries on cerebral hemisphere specialization and visual system information processing
|
|
46
|
1980
|
Baruj Benacerraf, Jean Dausset, George D. Snell
|
Discoveries concerning genetically determined structures regulating immunological reactions
|
|
47
|
1979
|
Allan M. Cormack, Godfrey N. Hounsfield
|
Development of computer-assisted tomography
|
|
48
|
1978
|
Werner Arber, Daniel Nathans, Hamilton O. Smith
|
Discovery of restriction enzymes and their application in molecular genetics
|
|
49
|
1977
|
Roger Guillemin, Andrew V. Schally, Rosalyn Yalow
|
Discoveries on peptide hormone production and radioimmunoassays
|
|
50
|
1976
|
Baruch S. Blumberg, D. Carleton Gajdusek
|
Discoveries on new mechanisms for origin and dissemination of infectious diseases
|
|
51
|
1975
|
David Baltimore, Renato Dulbecco, Howard M. Temin
|
Discoveries on interaction between tumor viruses and genetic material
|
|
52
|
1974
|
Albert Claude, Christian de Duve, George E. Palade
|
Discoveries on structural and functional organization of the cell
|
|
53
|
1973
|
Karl von Frisch, Konrad Lorenz, Nikolaas Tinbergen
|
Discoveries concerning individual and social behaviour patterns
|
|
54
|
1972
|
Gerald M. Edelman, Rodney R. Porter
|
Discoveries concerning chemical structure of antibodies
|
|
55
|
1971
|
Earl W. Sutherland, Jr.
|
Discoveries on mechanisms of hormone action
|
|
56
|
1970
|
Sir Bernard Katz, Ulf von Euler, Julius Axelrod
|
Discoveries on humoral transmitters in nerve terminals
|
|
57
|
1969
|
Max Delbrück, Alfred D. Hershey, Salvador E. Luria
|
Discoveries on virus replication mechanism and genetic structure
|
|
58
|
1968
|
Robert W. Holley, H. Gobind Khorana, Marshall W. Nirenberg
|
Interpretation of genetic code and its role in protein synthesis
|
|
59
|
1967
|
Ragnar Granit, Keffer Hartline, George Wald
|
Discoveries on primary physiological and chemical visual processes
|
|
60
|
1966
|
Peyton Rous, Charles B. Huggins
|
Discovery of tumor-inducing viruses and hormonal treatment of prostatic cancer
|
|
61
|
1965
|
François Jacob, André Lwoff, Jacques Monod
|
Discoveries concerning genetic control of enzyme and virus synthesis
|
|
62
|
1964
|
Konrad Bloch, Feodor Lynen
|
Discoveries concerning mechanism and regulation of cholesterol and fatty acid metabolism
|
|
63
|
1963
|
Sir John Eccles, Alan Hodgkin, Andrew Huxley
|
Discoveries concerning ionic mechanisms in excitation and inhibition of nerve cells
|
|
64
|
1962
|
Francis Crick, James Watson, Maurice Wilkins
|
Discoveries concerning molecular structure of nucleic acids and its significance for information transfer
|
|
65
|
1961
|
Georg von Békésy
|
Discoveries of the physical mechanism of stimulation within the cochlea
|
|
66
|
1960
|
Sir Frank Macfarlane Burnet, Peter Medawar
|
Discovery of acquired immunological tolerance
|
|
67
|
1959
|
Severo Ochoa, Arthur Kornberg
|
Discovery of mechanisms in the biological synthesis of RNA and DNA
|
|
68
|
1958
|
George Beadle, Edward Tatum, Joshua Lederberg
|
Discovery that genes act by regulating chemical events and genetic recombination in bacteria
|
|
69
|
1957
|
Daniel Bovet
|
Discoveries relating to synthetic compounds inhibiting certain body substances, especially vascular system and skeletal muscles
|
|
70
|
1956
|
André F. Cournand, Werner Forssmann, Dickinson W. Richards
|
Discoveries concerning heart catheterization and circulatory system pathology
|
|
71
|
1955
|
Hugo Theorell
|
Discoveries concerning nature and mode of action of oxidation enzymes
|
|
72
|
1954
|
John F. Enders, Thomas H. Weller, Frederick C. Robbins
|
Discovery of poliomyelitis virus growth in tissue cultures
|
|
73
|
1953
|
Hans Krebs, Fritz Lipmann
|
Discovery of citric acid cycle and co-enzyme A in intermediary metabolism
|
|
74
|
1952
|
Selman A. Waksman
|
Discovery of streptomycin, first antibiotic effective against tuberculosis
|
|
75
|
1951
|
Max Theiler
|
Discoveries concerning yellow fever and its control
|
|
76
|
1950
|
Edward C. Kendall, Tadeus Reichstein, Philip S. Hench
|
Discoveries relating to adrenal cortex hormones, their structure and effects
|
|
77
|
1949
|
Walter Hess, Egas Moniz
|
Discovery of functional organization of the interbrain and therapeutic value of leucotomy
|
|
78
|
1948
|
Paul Müller
|
Discovery of high efficiency of DDT as contact poison against arthropods
|
|
79
|
1947
|
Carl Cori, Gerty Cori, Bernardo Houssay
|
Discovery of catalytic conversion of glycogen and hormone role in sugar metabolism
|
|
80
|
1946
|
Hermann J. Muller
|
Discovery of mutation production by X-ray irradiation
|
|
81
|
1945
|
Sir Alexander Fleming, Ernst B. Chain, Sir Howard Florey
|
Discovery of penicillin and its curative effect in infectious diseases
|
|
82
|
1944
|
Joseph Erlanger, Herbert S. Gasser
|
Discoveries on highly differentiated functions of single nerve fibers
|
|
83
|
1943
|
Henrik Dam, Edward A. Doisy
|
Discovery of vitamin K and its chemical nature
|
|
84
|
1942
|
Not awarded
|
Prize money allocated to main and special fund
|
|
85
|
1941
|
Not awarded
|
Prize money allocated to main and special fund
|
|
86
|
1940
|
Not awarded
|
Prize money allocated to main and special fund
|
|
87
|
1939
|
Gerhard Domagk
|
Discovery of antibacterial effects of prontosil
|
|
88
|
1938
|
Corneille Heymans
|
Discovery of role of sinus and aortic mechanisms in respiration regulation
|
|
89
|
1937
|
Albert Szent-Györgyi
|
Discoveries in biological combustion processes, vitamin C, catalysis of fumaric acid
|
|
90
|
1936
|
Sir Henry Dale, Otto Loewi
|
Discoveries relating to chemical transmission of nerve impulses
|
|
91
|
1935
|
Hans Spemann
|
Discovery of the organizer effect in embryonic development
|
|
92
|
1934
|
George H. Whipple, George R. Minot, William P. Murphy
|
Discoveries concerning liver therapy in anemia
|
|
93
|
1933
|
Thomas H. Morgan
|
Discoveries concerning chromosome role in heredity
|
|
94
|
1932
|
Sir Charles Sherrington, Edgar Adrian
|
Discoveries regarding neuron functions
|
|
95
|
1931
|
Otto Warburg
|
Discovery of nature and mode of action of respiratory enzyme
|
|
96
|
1930
|
Karl Landsteiner
|
Discovery of human blood groups
|
|
97
|
1929
|
Christiaan Eijkman, Sir Frederick Hopkins
|
Discovery of antineuritic vitamin and growth-stimulating vitamins
|
|
98
|
1928
|
Charles Nicolle
|
Work on typhus
|
|
99
|
1927
|
Julius Wagner-Jauregg
|
Discovery of therapeutic value of malaria inoculation in dementia paralytica
|
|
100
|
1926
|
Johannes Fibiger
|
Discovery of Spiroptera carcinoma
|
|
101
|
1925
|
Not awarded
|
Prize money allocated to special fund
|
|
102
|
1924
|
Willem Einthoven
|
Discovery of electrocardiogram mechanism
|
|
103
|
1923
|
Frederick G. Banting, John Macleod
|
Discovery of insulin
|
|
104
|
1922
|
Archibald V. Hill, Otto Meyerhof
|
Discoveries relating to heat production in muscle and oxygen-lactic acid metabolism
|
|
105
|
1921
|
Not awarded
|
Prize money allocated to special fund
|
|
106
|
1920
|
August Krogh
|
Discovery of capillary motor regulating mechanism
|
|
107
|
1919
|
Jules Bordet
|
Discoveries relating to immunity
|
|
108
|
1918
|
Not awarded
|
Prize money allocated to special fund
|
|
109
|
1917
|
Not awarded
|
Prize money allocated to special fund
|
|
110
|
1916
|
Not awarded
|
Prize money allocated to special fund
|
|
111
|
1915
|
Not awarded
|
Prize money allocated to special fund
|
|
112
|
1914
|
Robert Bárány
|
Work on physiology and pathology of vestibular apparatus
|
|
113
|
1913
|
Charles Richet
|
Work on anaphylaxis
|
|
114
|
1912
|
Alexis Carrel
|
Work on vascular suture and organ transplantation
|
|
115
|
1911
|
Allvar Gullstrand
|
Work on dioptrics of the eye
|
|
116
|
1910
|
Albrecht Kossel
|
Contributions to cell chemistry through work on proteins and nucleic substances
|
|
117
|
1909
|
Theodor Kocher
|
Work on physiology, pathology, and surgery of thyroid gland
|
|
118
|
1908
|
Ilya Mechnikov, Paul Ehrlich
|
Work on immunity
|
|
119
|
1907
|
Alphonse Laveran
|
Work on role of protozoa in causing diseases
|
|
120
|
1906
|
Camillo Golgi, Santiago Ramón y Cajal
|
Work on structure of nervous system
|
|
121
|
1905
|
Robert Koch
|
Investigations and discoveries in relation to tuberculosis
|
|
122
|
1904
|
Ivan Pavlov
|
Work on physiology of digestion
|
|
123
|
1903
|
Niels Ryberg Finsen
|
Contribution to treatment of diseases using concentrated light radiation
|
|
124
|
1902
|
Ronald Ross
|
Work on malaria, showing its entry into the organism and methods to combat it
|
|
125
|
1901
|
Emil von Behring
|
Work on serum therapy, especially against diphtheria
|