Reverse Vaccinology

Reverse Vaccinology Latest News

Recently, a team of British scientists have taken an important first step in developing a vaccine against pneumonia by using reverse vaccinology.

About Reverse Vaccinology

• It is an emerging concept in the field of vaccine development.
• It is defined as an innovative approach to vaccine development that utilizes bioinformatics and computational analysis.
• It identifies potential vaccine targets within pathogen genomes, allowing for the modeling of epitopes and the creation of tailored vaccines for improved efficacy and safety.
• Reverse vaccinology is a term coined by Rino Rappuoli in 2000.
• He described it as a method for vaccine design that uses the information obtainable from whole-genome analysis 
• It was first applied to development of a vaccine against serogroup B Neisseria meningitidis (MenB). 
• The concept of reverse vaccinology has also successfully been applied to many other pathogens, for example, Bacillus anthracis, Streptococcus pneumonia, M. tuberculosis.
• Mechanism
  • Genome Sequencing: It involves the cloning and expression of all the proteins in an organism’s genome sequence that are predicted in silico to be surface exposed or secreted.
  • Screening: Then each protein is screened, through high-throughput immunization.
  • Laboratory Testing: Scientists make the chosen proteins in a lab and test them in animal models to see if they safely cause immunity.

Source: TH

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