N-nitrosodimethylamine (NDMA)

N-Nitrosodimethylamine (NDMA) Latest News

Recently, drug regulator DCGI has asked drug controllers of all states and Union Territories to direct manufacturers under their jurisdiction to monitor the presence of a potentially carcinogenic chemical — N-Nitrosodimethylamine — in antacid Ranitidine.

About N-Nitrosodimethylamine

• It is a volatile organic chemical that occurs widely in the environment due to its ready formation from commonly found precursors.
• It is classified as a probable human carcinogen (a substance that could cause cancer) on the basis of animal studies.
• NDMA are formed when a secondary or tertiary amine reacts with a nitrite ion under acidic conditions.

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Features of N-Nitrosodimethylamine

• It is a yellow, odorless liquid chemical once used to make rocket fuel.
• It is also a byproduct of several manufacturing processes and water chlorination.
• NDMA breaks down when sunlight hits it.
• Applications: Historically it was commercially used in the production of rocket fuel, antioxidants, softeners for copolymers, and additives for lubricants.

Exposure to N-Nitrosodimethylamine

• Normally, people are exposed to small amounts of NDMA in the environment and through food and water.
• Chemicals found in food and water, such as nitrosamines or alkylamines, can turn into NDMA in the stomach.
• NDMA is also created when food or drink is processed. Foods such as cured meats (particularly bacon), beer, fish, cheese and even vegetables may contain NDMA.
• Some people may have had exposure to NDMA through the use of contaminated medications

Source: ET