Pioxaniliprole: India’s First Indigenous Insecticide Molecule, Mechanism of Action and Uses

Pioxaniliprole  Latest News

PI Industries Ltd’s Pioxaniliprole has received approval from the Central Insecticides Board and Registration Committee (CIBRC).

About Pioxaniliprole

• It is India’s first indigenously discovered insecticide molecule.
• It has been developed by PI Industries Ltd.
• It is an insecticidal active ingredient belonging to the anthranilic diamide class of insecticides.
• Pioxaniliprole’s Chemical Composition: It is a carboxamide compound containing chlorine, nitrogen, oxygen and sulphur atoms. 
• Mechanism of action
• • Target insect pests: The insecticide is effective against yellow stem borer, leaf folder, fall armyworm, tobacco cutworm, fruit borer and pod borer.
  • It targets ryanodine receptors in insects, causing feeding cessation, muscle paralysis and eventually death.
  • Pioxaniliprole acts by targeting ryanodine receptors (RyRs), specialised protein channels present in insect muscle cells that regulate the release of calcium ions from intracellular storage compartments into the cell cytoplasm.
    • Calcium ions play a crucial role in normal muscle contraction and relaxation. Pioxaniliprole binds to and activates these receptors, triggering an uncontrolled release of calcium ions.
  • This disrupts normal muscle functioning in insects, leading to feeding cessation, lethargy, muscle paralysis and eventually death.

Source: IE

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