Di-2-ethylhexyl Phthalate (DEHP)

Di-2-ethylhexyl Phthalate (DEHP) Latest News

A recent study in The Lancet eBioMedicine found a strong correlation between exposure to Di-2-ethylhexyl phthalate (DEHP) and increased cardiovascular mortality, especially in the 55–64 age group.

About Di-2-ethylhexyl Phthalate (DEHP) 

• Di-2-ethylhexyl phthalate (DEHP) is a synthetic chemical primarily used as a plasticiser, meaning it is added to plastics to make them more flexible, durable, and resistant to breaking.
• DEHP is a colourless, oily liquid with little to no odour, and is soluble in oils but not in water. It is widely used in the manufacture of polyvinyl chloride (PVC) plastics.
• Alternate names for DEHP include Dioctyl Phthalate (DOP) and Bis(2-ethylhexyl) Phthalate (BEHP), often found in industrial and consumer products.
• DEHP is prevalent in everyday items, such as food packaging materials, medical devices (like IV tubes), children’s toys, shampoos, lotions, and vinyl flooring, making human exposure widespread and continuous.
• In 2018, exposure to DEHP was linked to around 356,238 global deaths in that age group, accounting for over 13% of global cardiovascular deaths for individuals aged 55–64.
• India accounted for the highest number of DEHP-related cardiovascular deaths globally, with an estimated 103,587 deaths, nearly one-third of the global burden.
• DEHP is known to cause inflammation in coronary arteries, thereby increasing the risk of heart attacks and strokes over time.
• Apart from cardiovascular issues, DEHP exposure is associated with multiple health disorders, including:
  • Obesity and Type 2 diabetes
  • Hormonal disruptions and infertility
  • Increased risk of certain cancers
  • Premature birth and developmental disorders in infants
• About 75% of the global DEHP-related deaths occurred in regions like Asia, the Middle East, and the Pacific, highlighting the disproportionate burden on developing countries.

Source: DTE

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