Ethambutol Hydrochloride

Ethambutol Hydrochloride Latest News

India recently launched an anti-dumping investigation on imports of tuberculosis drug Ethambutol Hydrochloride from China and Thailand.

About Ethambutol Hydrochloride

• It is an antibacterial prescription medicine used for the treatment of tuberculosis (TB).
• It is a synthetic, water soluble, heat stable compound. 
• It is specifically effective against actively growing microorganisms of the genus Mycobacterium including M. tuberculosis. 
• It is used to combat both pulmonary and extrapulmonary tuberculosis. 
• Mechanism:
  • Ethambutol (HCl) specifically targets the synthesis of the cell wall in M. tuberculosis. 
  • By interfering with the polymerization of arabinogalactan, a key component of the mycobacterial cell wall, Ethambutol disrupts the structural integrity of the bacteria, leading to its demise.
  • Its unique mode of action is fundamental in combination therapies, where it is often used in conjunction with other anti-tubercular drugs to prevent resistance and enhance efficacy.
• Resistance to ethambutol emerges rapidly when the drug is used alone. Therefore ethambutol is always given in combination with other antituberculosis drugs.

Source: TH

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