Nimesulide

Nimesulide Latest News

The government recently prohibited the manufacturing, sale and distribution of all oral formulations containing Nimesulide above 100 mg with immediate effect.

About Nimesulide

• First introduced in Italy in 1985, it is a non-steroidal anti-inflammatory drug (NSAID) used for its pain-relieving, anti-inflammatory, and fever-reducing effects.
• It is commonly used to manage acute pain, musculoskeletal disorders, dental pain, and symptoms associated with conditions such as osteoarthritis and dysmenorrhea.
• Nimesulide works by inhibiting the action of cyclooxygenase (COX), an enzyme responsible for the production of prostaglandins-chemicals that cause pain, inflammation, and fever.
• By blocking this enzyme, Nimesulide reduces the levels of prostaglandins, thus providing relief from pain and inflammation.
• By targeting the underlying inflammatory process rather than just masking the pain, Nimesulide helps relieve swelling, improves mobility and function in affected areas, and enhances overall comfort and quality of life.

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Side Effects of Nimesulide

• Long-term usage may harm the liver or result in significant side effects, including gastrointestinal bleeding or renal issues.
• Apart from this, other side effects like sour stomach, dizziness, skin infection, diarrhoea, and increased liver enzymes might be observed in individuals.

Regulation of Nimesulide

• From its early years, nimesulide attracted safety concerns and was never approved for use in countries including the United States, the UK, Canada, Australia, New Zealand, and Japan.
• In 2008, the International Society of Drug Bulletins, a WHO-supported network, called for a global ban on nimesulide.
• India banned the use of nimesulide in children below 12 years of age in 2011 but continued to allow its use in older patients. However, concerns have persisted.

Source: News On Air