Zimislecel Therapy

Zimislecel Therapy Latest News

A small clinical trial, published in The New England Journal of Medicine, tested a therapy called zimislecel which can help in restoring insulin in people with type 1 diabetes.

About Zimislecel Therapy

• It is a new allogeneic stem cell-derived islet cell therapy in which islet cells are infused into the liver.
• The pancreas contains clusters of cells that produce hormones. These clusters are known as islets.
• Scientists made zimislecel by growing islets from pluripotent stem cells in the lab.
• These are matured into functioning islets and infused into the hepatic portal vein.
• The hope is that these cells will take root, survive, and begin producing insulin from within the body.
• Zimislecel has the potential to restore the body’s ability to regulate glucose levels by restoring pancreatic islet cell function, including glucose-responsive insulin production
• These lab-grown cells began producing insulin again, improving blood sugar control, preventing dangerous lows, and, in most cases, eliminating the need for insulin.

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What is Type 1 Diabetes?

• It is a condition in which your immune system destroys insulin-making cells in your pancreas. These are called beta cells.
• When you have type 1 diabetes, your body produces very little or no insulin.
• It requires daily administration of insulin to maintain blood glucose levels under control.
• It is usually diagnosed in children and young people, so it used to be called juvenile diabetes.
• Symptoms include excessive excretion of urine (polyuria), thirst (polydipsia), constant hunger, weight loss, vision changes, and fatigue.

Source: TH