UPSC Prelims Current Affairs for 6 September 2025

HealthAI Global Regulatory Network

September 6, 2025

HealthAI Global Regulatory Network Latest News

Recently, India joined Health AI Global Regulatory Network (GRN) to strengthen oversight of AI in healthcare.

About HealthAI Global Regulatory Network

It is a Geneva-based, independent nonprofit organization that promotes equitable access to AI-powered health innovations.
It is a global network of health regulators dedicated to the safe and effective use of artificial intelligence (AI) in healthcare.
It aims to build trust, improve safety and accelerate responsible innovation through shared learning, joint standards and early warnings of emerging risks.
Members of this network group will also have access to a global directory of registered AI health tools to support transparency and collaboration.
The Indian Council of Medical Research -National Institute for Research in Digital Health and Data Science (ICMR - NIRDHDS), and IndiaAI will work with HealthAI.

What is IndiaAI?

It is the Government of India’s central initiative to build a comprehensive and inclusive AI ecosystem.
It is works under the Ministry of Electronics & Information Technology (MeitY) via the Digital India Corporation,
It aims to position India as a leader in AI innovation and development.

Source: PIB

HealthAI Global Regulatory Network FAQs

Q1: What is artificial intelligence?

Ans: It is technology that enables computers and machines to simulate human learning, comprehension, problem solving, decision making, creativity and autonomy.

Q2: What is the role of the Indian Council of Medical Research?

Ans: It develops and disseminates guidelines and regulations on a range of public health issues.

P-47 Protein

September 6, 2025

P-47 Protein Latest News

Researchers at the S. N. Bose National Centre for Basic Sciences (SNBNCBS) highlighted protein p47’s unexpected ability to act as a “mechanical chaperone.”

About P-47 Protein

It is a cofactor protein usually known as a helper for the cellular machine p97 (It is a powerhouse involved in moving and degrading proteins).
It was long thought to be just an assistant known primarily for its role in protein trafficking, degradation, and membrane fusion.

Highlight of the Study

It is revealed that p47 can enhance the mechanical efficiency of protein extraction from the endoplasmic reticulum (ER) lumen into the cytoplasm.
P47 stabilizes polypeptides under stress and guides them through narrow pores, reduces the risk of misfolding and improves the success of protein translocation.
This finding represents the first direct, single-molecule evidence that cofactors like p47 possess autonomous, force-dependent chaperone-like activity.
It is found that p47 is not just a passive helper for p97, it can directly stabilize proteins under force, effectively acting as a “mechanical chaperone.”
The findings suggest that targeting mechanical cofactors like p47 could lead to novel therapeutic strategies for diseases linked to protein instability.

Source: PIB

P-47 Protein FAQs

Q1: What is called protein?

Ans: Proteins are large, complex molecules that play many critical roles in the body.

Q2: What is chaperone and its function?

Ans: Chaperones are a family of proteins that play a vital role in the stabilization of unfolded proteins.

Vulture Network Portal

September 6, 2025

Vulture Network Portal Latest News

Recently, an Assam-based foundation developed the Vulture Network portal.

About Vulture Network Portal

It is a cloud-based portal designed to serve as a comprehensive knowledge and awareness platform on vultures of India.
It is first of its kind in India - to build a network of individuals engaged in saving the large scavenger birds.
It was started by We Foundation India supported by dedicated partners such as the Assam Bird Monitoring Network and other organisations.
Purpose: It was developed to compile scientific information, spread awareness, and provide freely downloadable outreach materials for anyone interested in conducting awareness campaigns.
It focuses on the threats of carcass poisoning, harmful veterinary drugs such as diclofenac, and negative social perceptions, all of which continue to drive vulture population decline.
It is disseminating information in local languages, beginning with Assamese.

Vultures Found in India

Slender-billed vulture(only about 800 mature individuals left) white-rumped vulture, red-headed vulture, Himalayan griffon, Indian vulture, cinereous vulture, Eurasian griffon, Egyptian vulture, and bearded vulture.

Source: TH

Vulture Network Portal FAQ's

Q1: What is a cloud-based portal?

Ans: A cloud portal is a web-based interface that allows users to access and manage cloud services and resources.

Q2: What is the IUCN status of slender billed vulture?

Ans: Critically Endangered

Methandienone Long-Term Metabolite

September 6, 2025

Methandienone Long-Term Metabolite Latest News

India has successfully developed a rare and high-purity Reference Material (RM) – Methandienone Long-Term Metabolite (LTM) for enhanced Anti-Doping Testing in sports.

About Methandienone Long-Term Metabolite

It is one of the Reference Material (RM) developed by the National Institute of Pharmaceutical Education and Research (NIPER) in collaboration with the National Dope Testing Laboratory (NDTL).
- RM is the most highly purified and scientifically characterized forms of drug substances or their metabolites, essential for accurate analytical testing.
- They are crucial for the detection of over 450 substances that are currently prohibited by the World Anti-Doping Agency (WADA).

Significance of Methandienone Long-Term Metabolite

These metabolites help in identifying athletes who have used Methandienone
It will increase improved detection capabilities and serve as a deterrent for athletes considering the use of anabolic steroids like Methandienone.
The new reference material will help in enforcing transparency and integrity in sports by protecting clean athletes and acting as deterrents for use of prohibited substances.

Key Facts about National Dope Testing Laboratory

It is a premier analytical testing & research organization established under Government of India.
It is the only laboratory in the country responsible for human sports dope testing.
It is accredited by National Accreditation Board for Testing & Calibration Laboratories, NABL and World Anti-Doping Agency (WADA).

Source: PIB

Methandienone Long-Term Metabolite FAQs

Q1: Where is the World Anti-Doping Agency located?

Ans: Montreal, Canada

Q2: What are examples of a metabolite?

Ans: Examples of primary metabolites are ethanol, glutamic acid, aspartic acid, 5′ guanylic acid, acetic acid, lactic acid, glycerol etc.

Mission Mausam

September 6, 2025

Mission Mausam Latest News

The Indian Meteorological Department (IMD) will install four additional radars under Mission Mausam in Jammu & Kashmir for more accurate, district wise specific weather forecasts.

About Mission Mausam

It was launched by the Ministry of Earth Sciences in 2024.
It is implemented by the India Meteorological Department (IMD), the National Centre for Medium-Range Weather Forecasting (NCMRWF), and the Indian Institute of Tropical Meteorology (IITM).
It aims to improve weather and climate services, ensuring timely and precise observation, modeling, and forecasting information for multiple sectors, including agriculture, disaster management, and rural development.

Objectives of Mission Mausam

To enhance India's capability in weather forecasting across various scales—short-term, medium-term, extended-range, and seasonal
To develop high-resolution models for improved accuracy in predicting monsoon behaviour
To strengthen observational networks with advanced radars, satellites, and automated weather stations
To provide actionable advisories for agriculture, water resources, energy, health, and disaster management sectors
To build capacity through research collaborations with national and international institutions

Significance of Mission Mausam

It marks a transformative milestone in India's efforts to address climate variability and its far-reaching socio-economic impacts.
It supports sustainable development while safeguarding lives, livelihoods, and critical infrastructure.

Source: PIB

Mission Mausam FAQs

Q1: What is the purpose India Meteorological Department (IMD)?

Ans: It is the principal agency responsible for meteorological observations, weather forecasting and seismology.

Q2: Where is the headquarter of Meteorology in India?

Ans: New Delhi

MY Bharat

September 6, 2025

MY Bharat Latest News

Union Minister of Sports and Youth Affairs stated that MY Bharat Aapda Mitras will be mobilised to provide rescue operations in the flood-affected areas of Punjab and Himachal Pradesh.

About MY Bharat

It is an autonomous body that has been set up by the Department of Youth Affairs, Ministry of Youth Affairs and Sport.
MY Bharat’s digital platform provides equitable access to opportunities for youth to actualize their aspirations and build Viksit Bharat.
It is meticulously designed to cater to the needs of the dynamic youth demographic, aged between 15 and 29 years.
This platform offers a wealth of resources, mentorship programs, experiential learning opportunities, networks, and invaluable industry connections.

Key Facts about MY Bharat Aapda Mitras

They are trained by the National Disaster Management Authority (NDMA) under the Aapda Mitra programme.
- Aapda Mitra programme is a unique initiative under MY Bharat, offering structured NDMA-certified disaster response training to young volunteers.
- It equips them with skills in search and rescue, first aid, crowd management, and emergency coordination, making them valuable assets during natural calamities.
- These youth volunteers will work at the grassroots to ensure that food, medical aid, and essential supplies reach villages cut off due to floods and landslides.

Source: News On Air

MY Bharat FAQs

Q1: What is National Disaster Management Authority and its role?

Ans: National Disaster Management Authority is an apex Body of Government of India, with a mandate to lay down policies for disaster management.

Q2: What is aapda mitra training?

Ans: It is to provide the community volunteers with the basic skills they will require for responding to their community's immediate needs in the aftermath of a disaster.

International Centre for Integrated Mountain Development

September 6, 2025

International Centre for Integrated Mountain Development Latest News

The International Centre for Integrated Mountain Development (ICIMOD) in its report said that the Hindu Kush Himalayas (HKH) region is tapping only 6.1% of its vast renewable energy potential.

About International Centre for Integrated Mountain Development

It is an intergovernmental knowledge and learning centre working on behalf of the people of the Hindu Kush Himalaya (HKH).
It was formally established and inaugurated on 5 December 1983.
Mission: To build and share knowledge that drives regional policy and action and attracts investment that enables the diverse countries and communities of the HKH to transition to greener, more inclusive, and climate resilient development.
Member countries: Afghanistan, Bangladesh, Bhutan, China, India, Myanmar, Nepal, and Pakistan.
Headquarter: Kathmandu, Nepal.

Functions of International Centre for Integrated Mountain Development

It serves the region through information and knowledge generation and sharing to find innovative solutions to critical mountain problems.
It bridges science with policies and on-the-ground practices.
It provides a regional platform where experts, planners, policymakers, and practitioners can exchange ideas and perspectives towards the achievement of sustainable mountain development.

Key Facts about Hindu Kush Himalaya

It extends around 3,500 km over eight countries — Afghanistan, Bangladesh, Bhutan, China, India, Nepal, Myanmar, and Pakistan.
It is considered the Third Pole (after the North and South Poles) and has significant implications for climate.
It forms the largest area of permanent ice cover outside of the North and South Poles and is home to 4 global biodiversity hotspots.
It is the source of ten large Asian river systems: the Amu Darya, Indus, Ganges, Brahmaputra, Irrawaddy, Salween, Mekong, Yangtse, Yellow River, and Tarim.

Source:DTE

International Centre for Integrated Mountain Development FAQs

Q1: Which countries are members of ICIMOD?

Ans: Afghanistan, Bangladesh, Bhutan, China, India, Myanmar, Nepal, and Pakistan

Q2: What is the International Centre for Integrated Mountain Development?

Ans: It is a focal point for research, institutional strengthening, cooperation, and information sharing among the mountain areas of Asia, especially in the Hindu Kush Himalayas.