CAR T-Cell Therapy Latest News
The clinical trial results of India’s first CAR T-cell therapy, published in The Lancet, show that it worked for nearly 73 percent of patients.
About CAR T-Cell Therapy
- CAR T-cell therapy, or chimeric antigen receptor T-cell therapy, trains the body’s own immune cells to identify and destroy cancer cells.
- This treatment is designed for specific types of blood cancer and is given to patients whose cancer has either relapsed or not responded to first-line treatment.
How does the Therapy Work?
- For any CAR T-cell therapy, a patient’s immune T-cells are collected by filtering their blood.
- These cells are then engineered in a lab to add receptors that can bind with cancer cells. These cells are then multiplied and infused in the patient.
- Usually, the cancer cells are adept at evading the unmodified T cells.
- The treatment developed in India is meant for patients with two types of blood cancers that affect the B cells — acute lymphoblastic leukemia and large B cell lymphomas.
Side Effects of CAR T Therapy
- A serious immune overreaction causing hyperinflammation and organ damage, seen in 12% of participants, resulting in at least one death.
- Low red blood cell count, reported in 61% of participants, causing fatigue and weakness.
- Thrombocytopenia: Low platelet count, increasing the risk of bleeding, reported in 65% of patients.
- Neutropenia: Low neutrophil count, seen in 96% of participants, raising the risk of infections.
CAR T Therapy FAQs
Q1: What does CAR T-cell therapy do?
Ans: CAR T-cell therapy genetically modifies a patient’s immune cells (T-cells) to effectively recognize and destroy cancer cells.
Q2: What is the controversy with CAR T-therapy?
Ans: CAR T-cell therapy faces controversy due to potential risks of causing secondary cancers, such as T-cell lymphomas, through unintended genetic mutations.
Q3: What diseases can CAR T-cell therapy treat?
Ans: CAR T-cell therapy treats certain blood cancers like lymphoma and leukemia, especially when other treatments have failed.
Source: IE
Last updated on June, 2025
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